Digitoxin analogues with improved anticytomegalovirus activity

Hongyi Cai, Hua Yu L Wang, Rajkumar Venkatadri, De Xue Fu, Michael Forman, Sumit O. Bajaj, Hongyan Li, George A. O'Doherty, Ravit Boger

Research output: Contribution to journalArticle

Abstract

Cardiac glycosides are potent inhibitors of cancer cell growth and possess antiviral activities at nanomolar concentrations. In this study we evaluated the anticytomegalovirus (CMV) activity of digitoxin and several of its analogues. We show that sugar type and sugar length attached to the steroid core structure affects its anticytomegalovirus activity. Structure-activity relationship (SAR) studies identified the l-sugar containing cardiac glycosides as having improved anti-CMV activity and may lead to better understanding of how these compounds inhibit CMV replication.

Original languageEnglish (US)
Pages (from-to)395-399
Number of pages5
JournalACS Medicinal Chemistry Letters
Volume5
Issue number4
DOIs
Publication statusPublished - Apr 10 2014

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Keywords

  • Cardiac glycosides
  • cytomegalovirus
  • digitoxin analogues
  • virus inhibition

ASJC Scopus subject areas

  • Organic Chemistry
  • Drug Discovery
  • Biochemistry

Cite this

Cai, H., Wang, H. Y. L., Venkatadri, R., Fu, D. X., Forman, M., Bajaj, S. O., ... Boger, R. (2014). Digitoxin analogues with improved anticytomegalovirus activity. ACS Medicinal Chemistry Letters, 5(4), 395-399. https://doi.org/10.1021/ml400529q