Digitoxin analogues with improved anticytomegalovirus activity

Hongyi Cai, Hua Yu L. Wang, Rajkumar Venkatadri, De Xue Fu, Michael Forman, Sumit O. Bajaj, Hongyan Li, George A. O'Doherty, Ravit Arav-Boger

Research output: Contribution to journalArticlepeer-review

Abstract

Cardiac glycosides are potent inhibitors of cancer cell growth and possess antiviral activities at nanomolar concentrations. In this study we evaluated the anticytomegalovirus (CMV) activity of digitoxin and several of its analogues. We show that sugar type and sugar length attached to the steroid core structure affects its anticytomegalovirus activity. Structure-activity relationship (SAR) studies identified the l-sugar containing cardiac glycosides as having improved anti-CMV activity and may lead to better understanding of how these compounds inhibit CMV replication.

Original languageEnglish (US)
Pages (from-to)395-399
Number of pages5
JournalACS Medicinal Chemistry Letters
Volume5
Issue number4
DOIs
StatePublished - Apr 10 2014

Keywords

  • Cardiac glycosides
  • cytomegalovirus
  • digitoxin analogues
  • virus inhibition

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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