Digitoxin analogues with improved anticytomegalovirus activity

Hongyi Cai; Hua Yu L. Wang; Rajkumar Venkatadri; De Xue Fu; Michael Forman; Sumit O. Bajaj; Hongyan Li; George A. O'Doherty; Ravit Arav-Boger

doi:10.1021/ml400529q

Digitoxin analogues with improved anticytomegalovirus activity

Hongyi Cai, Hua Yu L. Wang, Rajkumar Venkatadri, De Xue Fu, Michael Forman, Sumit O. Bajaj, Hongyan Li, George A. O'Doherty, Ravit Arav-Boger

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Cardiac glycosides are potent inhibitors of cancer cell growth and possess antiviral activities at nanomolar concentrations. In this study we evaluated the anticytomegalovirus (CMV) activity of digitoxin and several of its analogues. We show that sugar type and sugar length attached to the steroid core structure affects its anticytomegalovirus activity. Structure-activity relationship (SAR) studies identified the l-sugar containing cardiac glycosides as having improved anti-CMV activity and may lead to better understanding of how these compounds inhibit CMV replication.

Original language	English (US)
Pages (from-to)	395-399
Number of pages	5
Journal	ACS Medicinal Chemistry Letters
Volume	5
Issue number	4
DOIs	https://doi.org/10.1021/ml400529q
State	Published - Apr 10 2014
Externally published	Yes

Keywords

Cardiac glycosides
cytomegalovirus
digitoxin analogues
virus inhibition

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1021/ml400529q

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title = "Digitoxin analogues with improved anticytomegalovirus activity",

abstract = "Cardiac glycosides are potent inhibitors of cancer cell growth and possess antiviral activities at nanomolar concentrations. In this study we evaluated the anticytomegalovirus (CMV) activity of digitoxin and several of its analogues. We show that sugar type and sugar length attached to the steroid core structure affects its anticytomegalovirus activity. Structure-activity relationship (SAR) studies identified the l-sugar containing cardiac glycosides as having improved anti-CMV activity and may lead to better understanding of how these compounds inhibit CMV replication.",

keywords = "Cardiac glycosides, cytomegalovirus, digitoxin analogues, virus inhibition",

author = "Hongyi Cai and Wang, {Hua Yu L.} and Rajkumar Venkatadri and Fu, {De Xue} and Michael Forman and Bajaj, {Sumit O.} and Hongyan Li and O'Doherty, {George A.} and Ravit Arav-Boger",

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doi = "10.1021/ml400529q",

language = "English (US)",

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pages = "395--399",

journal = "ACS Medicinal Chemistry Letters",

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T1 - Digitoxin analogues with improved anticytomegalovirus activity

AU - Cai, Hongyi

AU - Wang, Hua Yu L.

AU - Venkatadri, Rajkumar

AU - Fu, De Xue

AU - Forman, Michael

AU - Bajaj, Sumit O.

AU - Li, Hongyan

AU - O'Doherty, George A.

AU - Arav-Boger, Ravit

PY - 2014/4/10

Y1 - 2014/4/10

N2 - Cardiac glycosides are potent inhibitors of cancer cell growth and possess antiviral activities at nanomolar concentrations. In this study we evaluated the anticytomegalovirus (CMV) activity of digitoxin and several of its analogues. We show that sugar type and sugar length attached to the steroid core structure affects its anticytomegalovirus activity. Structure-activity relationship (SAR) studies identified the l-sugar containing cardiac glycosides as having improved anti-CMV activity and may lead to better understanding of how these compounds inhibit CMV replication.

AB - Cardiac glycosides are potent inhibitors of cancer cell growth and possess antiviral activities at nanomolar concentrations. In this study we evaluated the anticytomegalovirus (CMV) activity of digitoxin and several of its analogues. We show that sugar type and sugar length attached to the steroid core structure affects its anticytomegalovirus activity. Structure-activity relationship (SAR) studies identified the l-sugar containing cardiac glycosides as having improved anti-CMV activity and may lead to better understanding of how these compounds inhibit CMV replication.

KW - Cardiac glycosides

KW - cytomegalovirus

KW - digitoxin analogues

KW - virus inhibition

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DO - 10.1021/ml400529q

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EP - 399

JO - ACS Medicinal Chemistry Letters

JF - ACS Medicinal Chemistry Letters

IS - 4

ER -

Digitoxin analogues with improved anticytomegalovirus activity

Abstract

Keywords

ASJC Scopus subject areas

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