Abstract
Three new Vitamin D analogs 3-5 incorporating a -CHF2 group as an -OH surrogate have been prepared. Two of these new analogs (3 and 5) are strongly antiproliferative toward murine keratinocytes and are approximately 50 times less calciuric in vivo than the natural hormone calcitriol. The transcriptional activity of the 25-CHF2 analog 3 is higher than that of the 1-CHF2 analog 4.
Original language | English (US) |
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Pages (from-to) | 213-221 |
Number of pages | 9 |
Journal | Journal of Steroid Biochemistry and Molecular Biology |
Volume | 103 |
Issue number | 3-5 |
DOIs | |
State | Published - Mar 2007 |
Keywords
- Fluorinated D analogs
- Growth inhibition
- Low-calcemic
- Protease digestion assay
- VDR binding
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Endocrinology
- Clinical Biochemistry
- Cell Biology