Difluorinated malonaldehyde derivatives as useful difluoromethylene- containing building blocks

Takashi Tsukamoto; Tomouya Kitazume

doi:10.1039/C39920000540

Difluorinated malonaldehyde derivatives as useful difluoromethylene- containing building blocks

Research output: Contribution to journal › Article › peer-review

Abstract

New CF₂-containing building blocks, ethyl 3-ethoxy-2,2-difluoro- 3-hydroxy-propionate and -propioamide, were prepared via formylation of α,α-difluorinated Reformatsky reagents, and reacted with active methylene compounds, nitromethane or phosphonoacetate to afford α,α-difluoro-functionalized esters and amides.

Original language	English (US)
Pages (from-to)	540-541
Number of pages	2
Journal	Journal of the Chemical Society, Chemical Communications
Issue number	7
DOIs	https://doi.org/10.1039/C39920000540
State	Published - Dec 1 1992
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine

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10.1039/C39920000540

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title = "Difluorinated malonaldehyde derivatives as useful difluoromethylene- containing building blocks",

abstract = "New CF2-containing building blocks, ethyl 3-ethoxy-2,2-difluoro- 3-hydroxy-propionate and -propioamide, were prepared via formylation of α,α-difluorinated Reformatsky reagents, and reacted with active methylene compounds, nitromethane or phosphonoacetate to afford α,α-difluoro-functionalized esters and amides.",

author = "Takashi Tsukamoto and Tomouya Kitazume",

year = "1992",

month = dec,

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doi = "10.1039/C39920000540",

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N2 - New CF2-containing building blocks, ethyl 3-ethoxy-2,2-difluoro- 3-hydroxy-propionate and -propioamide, were prepared via formylation of α,α-difluorinated Reformatsky reagents, and reacted with active methylene compounds, nitromethane or phosphonoacetate to afford α,α-difluoro-functionalized esters and amides.

AB - New CF2-containing building blocks, ethyl 3-ethoxy-2,2-difluoro- 3-hydroxy-propionate and -propioamide, were prepared via formylation of α,α-difluorinated Reformatsky reagents, and reacted with active methylene compounds, nitromethane or phosphonoacetate to afford α,α-difluoro-functionalized esters and amides.

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