Difluorinated malonaldehyde derivatives as useful difluoromethylene- containing building blocks

Takashi Tsukamoto, Tomouya Kitazume

Research output: Contribution to journalArticlepeer-review

Abstract

New CF2-containing building blocks, ethyl 3-ethoxy-2,2-difluoro- 3-hydroxy-propionate and -propioamide, were prepared via formylation of α,α-difluorinated Reformatsky reagents, and reacted with active methylene compounds, nitromethane or phosphonoacetate to afford α,α-difluoro-functionalized esters and amides.

Original languageEnglish (US)
Pages (from-to)540-541
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number7
DOIs
StatePublished - Dec 1 1992
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine

Fingerprint Dive into the research topics of 'Difluorinated malonaldehyde derivatives as useful difluoromethylene- containing building blocks'. Together they form a unique fingerprint.

Cite this