New CF2-containing building blocks, ethyl 3-ethoxy-2,2-difluoro- 3-hydroxy-propionate and -propioamide, were prepared via formylation of α,α-difluorinated Reformatsky reagents, and reacted with active methylene compounds, nitromethane or phosphonoacetate to afford α,α-difluoro-functionalized esters and amides.
|Original language||English (US)|
|Number of pages||2|
|Journal||Journal of the Chemical Society, Chemical Communications|
|State||Published - Dec 1 1992|
ASJC Scopus subject areas
- Molecular Medicine