Abstract
New CF2-containing building blocks, ethyl 3-ethoxy-2,2-difluoro- 3-hydroxy-propionate and -propioamide, were prepared via formylation of α,α-difluorinated Reformatsky reagents, and reacted with active methylene compounds, nitromethane or phosphonoacetate to afford α,α-difluoro-functionalized esters and amides.
Original language | English (US) |
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Pages (from-to) | 540-541 |
Number of pages | 2 |
Journal | Journal of the Chemical Society, Chemical Communications |
Issue number | 7 |
DOIs | |
State | Published - Dec 1 1992 |
Externally published | Yes |
ASJC Scopus subject areas
- Molecular Medicine