Diffusionsgewichtete MRI: Ischämische und traumatische verletzungen des zentralnervensystems

Translated title of the contribution: Diffusion weighted magnetic resonance imaging: Ischemic and traumatic injury of the central nervous system

T. A G M Huisman, H. Hawighorst, C. H. Benoit, A. G. Sorensen

Research output: Contribution to journalArticle

Abstract

Diffusion weighted magnetic resonance imaging (DWI) represents a recent development that extends imaging from the depiction of the neuroanatomy into the field of functional and physiologic processes. DWI measures a fundamentally different physiologic parameter than conventional MRI. Image contrast is related to differences in the microscopic motion (diffusion) of water molecules within brain tissue rather than a change in total tissue water. Consequently, DWI can reveal pathology where conventional T1- and T2-weighted MR images are negative. DWI has clinically proven its value in the assessment of acute cerebral stroke and trauma by showing cerebral injury early due to ist ability to discriminate between lesions with cytotoxic edema (decreased diffusion) from lesions with vasogenic edema (increased diffusion). Full tensor DWI allows to calculate a variety of functional maps, the most widely used maps include maps of apparent diffusion coefficients and isotropic diffusion. In addition maps of anisotropic diffusion can be calculated which are believed to give information about the integrity and location of fiber tracts. This functional-anatomical information will most probably play an increasingly important role in the early detection of primary and secondary tissue injury from various reasons and could guide and validate current and future neuroprotective treatments.

Translated title of the contributionDiffusion weighted magnetic resonance imaging: Ischemic and traumatic injury of the central nervous system
Original languageGerman
Pages (from-to)1038-1047
Number of pages10
JournalRadiologe
Volume41
Issue number12
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Anisotropic diffusion
  • Apparent diffusion coefficient
  • Diffusion weighted MRI
  • Stroke
  • Trauma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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  • Cite this

    Huisman, T. A. G. M., Hawighorst, H., Benoit, C. H., & Sorensen, A. G. (2001). Diffusionsgewichtete MRI: Ischämische und traumatische verletzungen des zentralnervensystems. Radiologe, 41(12), 1038-1047. https://doi.org/10.1007/s001170170003