TY - JOUR
T1 - Diffusion-weighted magnetic resonance imaging in distinguishing between mucin-producing and serous pancreatic cysts
AU - Pozzessere, Chiara
AU - Gutiérrez, Sandra Luz Castaños
AU - Corona-Villalobos, Celia Pamela
AU - Righi, Lorenzo
AU - Xu, Chunmiao
AU - Lennon, Anne Marie
AU - Wolfgang, Christopher L.
AU - Hruban, Ralph H.
AU - Goggins, Michael
AU - Canto, Marcia I.
AU - Kamel, Ihab R.
N1 - Publisher Copyright:
© 2016 Wolters Kluwer Health, Inc.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Objective The aim of this study was to evaluate the feasibility and reproducibility of diffusion-weighted imaging in distinguishing between mucin-producing and serous pancreatic cysts. Methods Forty-four pancreatic cysts (43 patients, 27 women; mean age, 57 years; 26 mucin-producing cysts, 18 serous cysts) that underwent histological examination or cyst analysis after diffusion-weighted magnetic resonance imaging were retrospectively reviewed. Three blinded readers independently evaluated signal intensity and apparent diffusion coefficient (ADC). Intraobserver and interobserver agreements were calculated. Fisher exact test and Welch t test were used to compare signal intensity and ADC values, respectively, with pathological results. Receiver operating characteristic analysis was used to determine diagnostic accuracy of various thresholds for ADC. A P value less than 0.05 was considered statistically significant. Results Mean ADC values of the mucin-producing cysts were 3.26 × 10-3, 3.27 × 10-3, and 3.35 × 10-3 mm2 /s for the 3 readers, respectively. Mean ADC values of the serous cysts were 2.86 × 10-3, 2.85 × 10-3, and 2.85 × 10-3 mm2 /s for the 3 readers, respectively. Differences in ADC values between the 2 cyst groups were 12.4%, 12.9%, and 14.8% for the 3 readers, respectively (P < 0.001). Intraobserver and interobserver agreement was excellent. A threshold ADC of 3 × 10-3 mm2 /s resulted in correct identification of cysts in 77% to 81% of cases, with sensitivity and specificity ranging between 84% and 88% and 66% and 72%, respectively. Conclusions Diffusion-weighted imaging may be a helpful tool in distinguishing between mucin-producing and serous pancreatic cysts.
AB - Objective The aim of this study was to evaluate the feasibility and reproducibility of diffusion-weighted imaging in distinguishing between mucin-producing and serous pancreatic cysts. Methods Forty-four pancreatic cysts (43 patients, 27 women; mean age, 57 years; 26 mucin-producing cysts, 18 serous cysts) that underwent histological examination or cyst analysis after diffusion-weighted magnetic resonance imaging were retrospectively reviewed. Three blinded readers independently evaluated signal intensity and apparent diffusion coefficient (ADC). Intraobserver and interobserver agreements were calculated. Fisher exact test and Welch t test were used to compare signal intensity and ADC values, respectively, with pathological results. Receiver operating characteristic analysis was used to determine diagnostic accuracy of various thresholds for ADC. A P value less than 0.05 was considered statistically significant. Results Mean ADC values of the mucin-producing cysts were 3.26 × 10-3, 3.27 × 10-3, and 3.35 × 10-3 mm2 /s for the 3 readers, respectively. Mean ADC values of the serous cysts were 2.86 × 10-3, 2.85 × 10-3, and 2.85 × 10-3 mm2 /s for the 3 readers, respectively. Differences in ADC values between the 2 cyst groups were 12.4%, 12.9%, and 14.8% for the 3 readers, respectively (P < 0.001). Intraobserver and interobserver agreement was excellent. A threshold ADC of 3 × 10-3 mm2 /s resulted in correct identification of cysts in 77% to 81% of cases, with sensitivity and specificity ranging between 84% and 88% and 66% and 72%, respectively. Conclusions Diffusion-weighted imaging may be a helpful tool in distinguishing between mucin-producing and serous pancreatic cysts.
KW - diffusion-weighted MRI
KW - intraductal papillary mucinous neoplasms
KW - mucinous cystic neoplasms
KW - pancreatic cyst
KW - serous cystadenomas
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U2 - 10.1097/RCT.0000000000000403
DO - 10.1097/RCT.0000000000000403
M3 - Article
C2 - 27023856
AN - SCOPUS:84961960693
SN - 0363-8715
VL - 40
SP - 505
EP - 512
JO - Journal of computer assisted tomography
JF - Journal of computer assisted tomography
IS - 4
ER -