TY - JOUR
T1 - Diffusion-weighted magnetic resonance imaging for predicting and detecting early response to chemoradiation therapy of squamous cell carcinomas of the head and neck
AU - Kim, Sungheon
AU - Loevner, Laurie
AU - Quon, Harry
AU - Sherman, Eric
AU - Weinstein, Gregory
AU - Kilger, Alex
AU - Poptani, Harish
PY - 2009/2/1
Y1 - 2009/2/1
N2 - Purpose: The aim of this study was to investigate the utility of apparent diffusion coefficient (ADC) for prediction and early detection of treatment response in head and neck squamous cell carcinomas (HNSCC). Experimental Design: Diffusion-weighted magnetic resonance imaging studies were performed on 40 patients with newly diagnosed HNSCC before, during, and after the end of chemoradiation therapy. Analysis was done on data from 33 patients after exclusion of 7 patients that had incomplete data. Results: Pretreatment ADC value of complete responders (1.04 ± 0.19 × 10 -3 mm 2/s) was significantly lower (P < 0.05) than that from partial responders (1.35 F 0.30 x 10 -3 mm 2/s). A significant increase in ADC was observedin complete responders within 1 week of treatent (P < 0.01), which remainedhigh until the endof the treatment. The complete responders also showed significantly higher increase in ADC than the partial responders by the first week of chemoradiation (P < 0.01). When pretreatment ADC value was usedfor predicting treatment response, the area under the receiver operating characteristic curve was 0.80 with a sensitivity of 65% anda specificity of 86%. However, change in ADC within the first week of chemoradiation therapy resulted in an area under the receiver operating characteristic curve of 0.88 with 86% sensitivity and83% specificity for prediction of treatment response. Conclusions: These results suggest that ADC can be usedas a marker for prediction and early detection of response to concurrent chemoradiation therapy in HNSCC.
AB - Purpose: The aim of this study was to investigate the utility of apparent diffusion coefficient (ADC) for prediction and early detection of treatment response in head and neck squamous cell carcinomas (HNSCC). Experimental Design: Diffusion-weighted magnetic resonance imaging studies were performed on 40 patients with newly diagnosed HNSCC before, during, and after the end of chemoradiation therapy. Analysis was done on data from 33 patients after exclusion of 7 patients that had incomplete data. Results: Pretreatment ADC value of complete responders (1.04 ± 0.19 × 10 -3 mm 2/s) was significantly lower (P < 0.05) than that from partial responders (1.35 F 0.30 x 10 -3 mm 2/s). A significant increase in ADC was observedin complete responders within 1 week of treatent (P < 0.01), which remainedhigh until the endof the treatment. The complete responders also showed significantly higher increase in ADC than the partial responders by the first week of chemoradiation (P < 0.01). When pretreatment ADC value was usedfor predicting treatment response, the area under the receiver operating characteristic curve was 0.80 with a sensitivity of 65% anda specificity of 86%. However, change in ADC within the first week of chemoradiation therapy resulted in an area under the receiver operating characteristic curve of 0.88 with 86% sensitivity and83% specificity for prediction of treatment response. Conclusions: These results suggest that ADC can be usedas a marker for prediction and early detection of response to concurrent chemoradiation therapy in HNSCC.
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U2 - 10.1158/1078-0432.CCR-08-1287
DO - 10.1158/1078-0432.CCR-08-1287
M3 - Article
C2 - 19188170
AN - SCOPUS:61549084040
SN - 1078-0432
VL - 15
SP - 986
EP - 994
JO - Clinical Cancer Research
JF - Clinical Cancer Research
IS - 3
ER -