Diffusion-weighted imaging with apparent diffusion coefficient mapping and spectroscopy in prostate cancer

Michael Jacobs, Ronald Ouwerkerk, Kyle Petrowski, Katarzyna Macura

Research output: Contribution to journalArticle

Abstract

Prostate cancer is a major health problem, and the exploration of noninvasive imaging methods that have the potential to improve specificity while maintaining high sensitivity is still critically needed. Tissue changes induced by tumor growth can be visualized by magnetic resonance imaging (MRI) methods. Current MRI methods include conventional T2-weighted imaging, diffusion-weighted imaging (DWI) with apparent diffusion coefficient (ADC) mapping and magnetic resonance spectroscopy (MRS). Techniques such as DWI/ADC provide functional information about the behavior of water molecules in tissue; MRS can provide biochemical information about the presence or absence of certain metabolites, such as choline, creatine, and citrate. Finally, vascular parameters can be investigated using dynamic contrast-enhanced MRI. Moreover, with whole-body MRI and DWI, metastatic disease can be evaluated in 1 session and may provide a way to monitor treatment. Therefore, when combining these various methods, a multiparametric data set can be built to assist in the detection, localization, assessment of prostate cancer aggressiveness, and tumor staging. Such a comprehensive approach offers more power to evaluate prostate disease than any single measure alone. In this article, we focus on the role of DWI/ADC and MRS in the detection and characterization using both in vivo and ex vivo imaging of prostate pathology.

Original languageEnglish (US)
Pages (from-to)261-272
Number of pages12
JournalTopics in Magnetic Resonance Imaging
Volume19
Issue number6
DOIs
StatePublished - Dec 2008
Externally publishedYes

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Spectrum Analysis
Prostatic Neoplasms
Magnetic Resonance Spectroscopy
Neoplasm Staging
Magnetic Resonance Imaging
Prostate
Diffusion Magnetic Resonance Imaging
Creatine
Choline
Blood Vessels
Pathology
Water
Health
Growth
Neoplasms

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Diffusion-weighted imaging with apparent diffusion coefficient mapping and spectroscopy in prostate cancer. / Jacobs, Michael; Ouwerkerk, Ronald; Petrowski, Kyle; Macura, Katarzyna.

In: Topics in Magnetic Resonance Imaging, Vol. 19, No. 6, 12.2008, p. 261-272.

Research output: Contribution to journalArticle

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