Diffusion-tensor MR imaging in children with developmental delay: Preliminary findings

Christopher G. Filippi, Doris Lin, Apostolos J. Tsiouris, Richard Watts, A. Maurine Packard, Linda A. Heier, Aziz M. Uluǧ

Research output: Contribution to journalArticle

Abstract

PURPOSE: To determine whether diffusion-tensor magnetic resonance (MR) imaging can depict abnormalities in patients with a diagnosis of developmental delay but structurally normal brain MR imaging results. MATERIALS AND METHODS: Twenty pediatric patients who received a diagnosis of developmental delay underwent brain MR examinations, including diffusiontensor MR imaging. The MR findings in these patients were compared with those in 10 age-matched neurodevelopmentally healthy children. Diffusion constant (Dav) and anisotropy were measured bilaterally in regions of interest in the centrum semiovale, corona radiata, internal capsule, corpus callosum, and subcortical white matter of the frontal and parieto-occipital lobes. By using a one-tailed Student t test in the positive direction for Dav and in the negative direction for anisotropy and P <.05 to indicate a significant difference, the Dav and anisotropy values for children with developmental delay were compared with those for children who were neurodevelopmentally healthy. RESULTS: The children with developmental delay had significant increases in Dav in all measured structures (P, av in the white matter fiber tracts, which appeared to be normal at conventional MR imaging.

Original languageEnglish (US)
Pages (from-to)44-50
Number of pages7
JournalRadiology
Volume229
Issue number1
DOIs
StatePublished - Oct 1 2003

Fingerprint

Diffusion Magnetic Resonance Imaging
Anisotropy
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Internal Capsule
Occipital Lobe
Corpus Callosum
Brain
Pediatrics
Students
White Matter
Direction compound

Keywords

  • Abnormalities
  • Brain
  • Central nervous system
  • Children
  • Diffusion study
  • Growth and development
  • Magnetic resonance (MR)

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Filippi, C. G., Lin, D., Tsiouris, A. J., Watts, R., Packard, A. M., Heier, L. A., & Uluǧ, A. M. (2003). Diffusion-tensor MR imaging in children with developmental delay: Preliminary findings. Radiology, 229(1), 44-50. https://doi.org/10.1148/radiol.2291020049

Diffusion-tensor MR imaging in children with developmental delay : Preliminary findings. / Filippi, Christopher G.; Lin, Doris; Tsiouris, Apostolos J.; Watts, Richard; Packard, A. Maurine; Heier, Linda A.; Uluǧ, Aziz M.

In: Radiology, Vol. 229, No. 1, 01.10.2003, p. 44-50.

Research output: Contribution to journalArticle

Filippi, CG, Lin, D, Tsiouris, AJ, Watts, R, Packard, AM, Heier, LA & Uluǧ, AM 2003, 'Diffusion-tensor MR imaging in children with developmental delay: Preliminary findings', Radiology, vol. 229, no. 1, pp. 44-50. https://doi.org/10.1148/radiol.2291020049
Filippi, Christopher G. ; Lin, Doris ; Tsiouris, Apostolos J. ; Watts, Richard ; Packard, A. Maurine ; Heier, Linda A. ; Uluǧ, Aziz M. / Diffusion-tensor MR imaging in children with developmental delay : Preliminary findings. In: Radiology. 2003 ; Vol. 229, No. 1. pp. 44-50.
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