TY - JOUR
T1 - Diffusion tensor imaging of the cervical spinal cord in children
AU - Orman, Gunes
AU - Wang, Kevin Yuqi
AU - Li, Ximin
AU - Thompson, Carol
AU - Huisman, Thierry A.G.M.
AU - Izbudak, Izlem
N1 - Funding Information:
Ximin Li and Carol Thompson’s work was supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health through Grant Number UL1T000424.
Publisher Copyright:
© 2015, Springer-Verlag Berlin Heidelberg.
PY - 2015/8/27
Y1 - 2015/8/27
N2 - Purpose: Obtaining fast, reliable, high-resolution diffusion tensor imaging (DTI) of the pediatric cervical spinal cord (CSC) is challenging, given the multitude of technical limitations involved. Overcoming these limitations may further potentiate DTI as a valuable quantitative tool in evaluating the pediatric CSC. Methods: Sixteen patients (9 girls and 7 boys) with hypoxic brain injury, craniocervical junction malformations, and head trauma were included in this retrospective study. Region of interests were placed from C1–C2 through C7–T1 consecutively at the cervical intervertebral disc levels. DTI metrics were compared with a pediatric DTI database of healthy controls. Clinical background and outcomes were tabulated. Results: Patients with hypoxic brain injury, Chiari I and II malformations, and head trauma demonstrated lower fractional anisotropy values than that of healthy controls at certain cervical intervertebral disc levels. Conclusions: DTI may be a promising modality for providing additional information beyond that of conventional magnetic resonance imaging in pediatric central nervous system disorders.
AB - Purpose: Obtaining fast, reliable, high-resolution diffusion tensor imaging (DTI) of the pediatric cervical spinal cord (CSC) is challenging, given the multitude of technical limitations involved. Overcoming these limitations may further potentiate DTI as a valuable quantitative tool in evaluating the pediatric CSC. Methods: Sixteen patients (9 girls and 7 boys) with hypoxic brain injury, craniocervical junction malformations, and head trauma were included in this retrospective study. Region of interests were placed from C1–C2 through C7–T1 consecutively at the cervical intervertebral disc levels. DTI metrics were compared with a pediatric DTI database of healthy controls. Clinical background and outcomes were tabulated. Results: Patients with hypoxic brain injury, Chiari I and II malformations, and head trauma demonstrated lower fractional anisotropy values than that of healthy controls at certain cervical intervertebral disc levels. Conclusions: DTI may be a promising modality for providing additional information beyond that of conventional magnetic resonance imaging in pediatric central nervous system disorders.
KW - Diffusion tensor imaging
KW - Fractional anisotropy
KW - Mean diffusivity
KW - Pediatric
KW - Spinal cord
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U2 - 10.1007/s00381-015-2767-6
DO - 10.1007/s00381-015-2767-6
M3 - Article
C2 - 26036198
AN - SCOPUS:84937967517
SN - 0256-7040
VL - 31
SP - 1239
EP - 1245
JO - Child's Nervous System
JF - Child's Nervous System
IS - 8
ER -