Diffusion tensor imaging of periventricular leukomalacia shows affected sensory cortex white matter pathways

A. H. Hoon, W. T. Lawrie, E. R. Melhem, E. M. Reinhardt, P. C.M. Van Zijl, M. Solaiyappan, H. Jiang, M. V. Johnston, S. Mori

Research output: Contribution to journalArticle

Abstract

The authors used diffusion-tensor imaging to examine central white matter pathways in two children with spastic quadriplegic cerebral palsy. Corticospinal tracts projecting from cortex to brainstem resembled controls. In contrast, posterior regions of the corpus callosum, internal capsule, and corona radiata were markedly reduced, primarily in white matter fibers connected to sensory cortex. These findings suggest that the motor impairment in periventricular leukomalacia may, in part, reflect disruption of sensory connections outside classic pyramidal motor pathways.

Original languageEnglish (US)
Pages (from-to)752-756
Number of pages5
JournalNeurology
Volume59
Issue number5
DOIs
StatePublished - Sep 10 2002

ASJC Scopus subject areas

  • Clinical Neurology

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