Diffusion tensor imaging of deep gray matter in children treated for brain malignancies

Alena Horská, Anna Nidecker, Jarunee Intrapiromkul, Firouzeh Tannazi, Siamak Ardekani, Larry J. Brant, Moody Wharam, Ernest M Mahone

Research output: Contribution to journalArticle

Abstract

Purpose: Previous DTI studies reported microstructural changes in white matter of patients receiving treatment for brain malignancies. The primary aim of this prospective pilot longitudinal study was to examine if DTI can detect microstructural changes in deep gray matter (as evaluated by the apparent diffusion coefficient, ADC) between pediatric patients treated with cranial radiation therapy and typically developing healthy children. The relationship between ADC and neurobehavioral performance was also examined. Methods: ADC was measured at 1.5 T in the caudate, putamen, globus pallidus, thalamus, and hippocampus in nine patients (mean age 11.8 years) and nine age-matched healthy controls. The study was designed with four visits: baseline, 6-month, 15-month, and 27-month follow-ups. Results: Patients had 24 % higher overall mean ADC in the hippocampus compared with controls (p∈=∈0.003). Post hoc analyses revealed significantly elevated ADC at baseline (p∈=∈0.003) and at the 27-month follow-up (p∈=∈0.006). Nevertheless, patients performed normally on a verbal memory test considered to be a hippocampus-related function. Relative to controls, patients' performance on the tests of the visual-spatial working memory decreased over time (group by visit, p∈=∈0.036). Both patients and controls showed a decline in motor speed with increasing ADC in the globus pallidus and putamen. Conclusions: Childhood brain malignancies and their treatment may affect gray matter microstructure as measured by water diffusion. Significant findings in the hippocampus but not other regions suggest that differences in tissue sensitivity to disease- and treatment-related injury among gray matter regions may exist. ADC in basal ganglia may be associated with motor performance.

Original languageEnglish (US)
Pages (from-to)631-638
Number of pages8
JournalChild's Nervous System
Volume30
Issue number4
DOIs
StatePublished - 2014

Fingerprint

Diffusion Tensor Imaging
Brain
Hippocampus
Neoplasms
Globus Pallidus
Putamen
Gray Matter
Basal Ganglia
Thalamus
Short-Term Memory
Longitudinal Studies
Radiotherapy
Therapeutics
Pediatrics
Water
Wounds and Injuries

Keywords

  • Basal ganglia
  • Brain
  • Children
  • Diffusion tensor imaging
  • Hippocampus
  • Radiation therapy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology
  • Medicine(all)

Cite this

Horská, A., Nidecker, A., Intrapiromkul, J., Tannazi, F., Ardekani, S., Brant, L. J., ... Mahone, E. M. (2014). Diffusion tensor imaging of deep gray matter in children treated for brain malignancies. Child's Nervous System, 30(4), 631-638. https://doi.org/10.1007/s00381-013-2315-1

Diffusion tensor imaging of deep gray matter in children treated for brain malignancies. / Horská, Alena; Nidecker, Anna; Intrapiromkul, Jarunee; Tannazi, Firouzeh; Ardekani, Siamak; Brant, Larry J.; Wharam, Moody; Mahone, Ernest M.

In: Child's Nervous System, Vol. 30, No. 4, 2014, p. 631-638.

Research output: Contribution to journalArticle

Horská, A, Nidecker, A, Intrapiromkul, J, Tannazi, F, Ardekani, S, Brant, LJ, Wharam, M & Mahone, EM 2014, 'Diffusion tensor imaging of deep gray matter in children treated for brain malignancies', Child's Nervous System, vol. 30, no. 4, pp. 631-638. https://doi.org/10.1007/s00381-013-2315-1
Horská A, Nidecker A, Intrapiromkul J, Tannazi F, Ardekani S, Brant LJ et al. Diffusion tensor imaging of deep gray matter in children treated for brain malignancies. Child's Nervous System. 2014;30(4):631-638. https://doi.org/10.1007/s00381-013-2315-1
Horská, Alena ; Nidecker, Anna ; Intrapiromkul, Jarunee ; Tannazi, Firouzeh ; Ardekani, Siamak ; Brant, Larry J. ; Wharam, Moody ; Mahone, Ernest M. / Diffusion tensor imaging of deep gray matter in children treated for brain malignancies. In: Child's Nervous System. 2014 ; Vol. 30, No. 4. pp. 631-638.
@article{ae55ee68a0c04105949acb82ae1684f0,
title = "Diffusion tensor imaging of deep gray matter in children treated for brain malignancies",
abstract = "Purpose: Previous DTI studies reported microstructural changes in white matter of patients receiving treatment for brain malignancies. The primary aim of this prospective pilot longitudinal study was to examine if DTI can detect microstructural changes in deep gray matter (as evaluated by the apparent diffusion coefficient, ADC) between pediatric patients treated with cranial radiation therapy and typically developing healthy children. The relationship between ADC and neurobehavioral performance was also examined. Methods: ADC was measured at 1.5 T in the caudate, putamen, globus pallidus, thalamus, and hippocampus in nine patients (mean age 11.8 years) and nine age-matched healthy controls. The study was designed with four visits: baseline, 6-month, 15-month, and 27-month follow-ups. Results: Patients had 24 {\%} higher overall mean ADC in the hippocampus compared with controls (p∈=∈0.003). Post hoc analyses revealed significantly elevated ADC at baseline (p∈=∈0.003) and at the 27-month follow-up (p∈=∈0.006). Nevertheless, patients performed normally on a verbal memory test considered to be a hippocampus-related function. Relative to controls, patients' performance on the tests of the visual-spatial working memory decreased over time (group by visit, p∈=∈0.036). Both patients and controls showed a decline in motor speed with increasing ADC in the globus pallidus and putamen. Conclusions: Childhood brain malignancies and their treatment may affect gray matter microstructure as measured by water diffusion. Significant findings in the hippocampus but not other regions suggest that differences in tissue sensitivity to disease- and treatment-related injury among gray matter regions may exist. ADC in basal ganglia may be associated with motor performance.",
keywords = "Basal ganglia, Brain, Children, Diffusion tensor imaging, Hippocampus, Radiation therapy",
author = "Alena Horsk{\'a} and Anna Nidecker and Jarunee Intrapiromkul and Firouzeh Tannazi and Siamak Ardekani and Brant, {Larry J.} and Moody Wharam and Mahone, {Ernest M}",
year = "2014",
doi = "10.1007/s00381-013-2315-1",
language = "English (US)",
volume = "30",
pages = "631--638",
journal = "Child's Nervous System",
issn = "0256-7040",
publisher = "Springer Verlag",
number = "4",

}

TY - JOUR

T1 - Diffusion tensor imaging of deep gray matter in children treated for brain malignancies

AU - Horská, Alena

AU - Nidecker, Anna

AU - Intrapiromkul, Jarunee

AU - Tannazi, Firouzeh

AU - Ardekani, Siamak

AU - Brant, Larry J.

AU - Wharam, Moody

AU - Mahone, Ernest M

PY - 2014

Y1 - 2014

N2 - Purpose: Previous DTI studies reported microstructural changes in white matter of patients receiving treatment for brain malignancies. The primary aim of this prospective pilot longitudinal study was to examine if DTI can detect microstructural changes in deep gray matter (as evaluated by the apparent diffusion coefficient, ADC) between pediatric patients treated with cranial radiation therapy and typically developing healthy children. The relationship between ADC and neurobehavioral performance was also examined. Methods: ADC was measured at 1.5 T in the caudate, putamen, globus pallidus, thalamus, and hippocampus in nine patients (mean age 11.8 years) and nine age-matched healthy controls. The study was designed with four visits: baseline, 6-month, 15-month, and 27-month follow-ups. Results: Patients had 24 % higher overall mean ADC in the hippocampus compared with controls (p∈=∈0.003). Post hoc analyses revealed significantly elevated ADC at baseline (p∈=∈0.003) and at the 27-month follow-up (p∈=∈0.006). Nevertheless, patients performed normally on a verbal memory test considered to be a hippocampus-related function. Relative to controls, patients' performance on the tests of the visual-spatial working memory decreased over time (group by visit, p∈=∈0.036). Both patients and controls showed a decline in motor speed with increasing ADC in the globus pallidus and putamen. Conclusions: Childhood brain malignancies and their treatment may affect gray matter microstructure as measured by water diffusion. Significant findings in the hippocampus but not other regions suggest that differences in tissue sensitivity to disease- and treatment-related injury among gray matter regions may exist. ADC in basal ganglia may be associated with motor performance.

AB - Purpose: Previous DTI studies reported microstructural changes in white matter of patients receiving treatment for brain malignancies. The primary aim of this prospective pilot longitudinal study was to examine if DTI can detect microstructural changes in deep gray matter (as evaluated by the apparent diffusion coefficient, ADC) between pediatric patients treated with cranial radiation therapy and typically developing healthy children. The relationship between ADC and neurobehavioral performance was also examined. Methods: ADC was measured at 1.5 T in the caudate, putamen, globus pallidus, thalamus, and hippocampus in nine patients (mean age 11.8 years) and nine age-matched healthy controls. The study was designed with four visits: baseline, 6-month, 15-month, and 27-month follow-ups. Results: Patients had 24 % higher overall mean ADC in the hippocampus compared with controls (p∈=∈0.003). Post hoc analyses revealed significantly elevated ADC at baseline (p∈=∈0.003) and at the 27-month follow-up (p∈=∈0.006). Nevertheless, patients performed normally on a verbal memory test considered to be a hippocampus-related function. Relative to controls, patients' performance on the tests of the visual-spatial working memory decreased over time (group by visit, p∈=∈0.036). Both patients and controls showed a decline in motor speed with increasing ADC in the globus pallidus and putamen. Conclusions: Childhood brain malignancies and their treatment may affect gray matter microstructure as measured by water diffusion. Significant findings in the hippocampus but not other regions suggest that differences in tissue sensitivity to disease- and treatment-related injury among gray matter regions may exist. ADC in basal ganglia may be associated with motor performance.

KW - Basal ganglia

KW - Brain

KW - Children

KW - Diffusion tensor imaging

KW - Hippocampus

KW - Radiation therapy

UR - http://www.scopus.com/inward/record.url?scp=84897520656&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84897520656&partnerID=8YFLogxK

U2 - 10.1007/s00381-013-2315-1

DO - 10.1007/s00381-013-2315-1

M3 - Article

VL - 30

SP - 631

EP - 638

JO - Child's Nervous System

JF - Child's Nervous System

SN - 0256-7040

IS - 4

ER -