Diffusion tensor imaging in children and adolescents: Reproducibility, hemispheric, and age-related differences

David Bonekamp, Lidia M. Nagae, Mahaveer Degaonkar, Melissa Matson, Wael M.A. Abdalla, Peter B. Barker, Susumu Mori, Alena Horská

Research output: Contribution to journalArticlepeer-review

202 Scopus citations


We evaluated intra-rater, inter-rater, and between-scan reproducibility, hemispheric differences, and the effect of age on apparent diffusion coefficient (ADC) and fractional anisotropy (FA) in healthy children (age range 5.5-19.1 years) examined with a clinical diffusion tensor imaging (DTI) protocol at 1.5 T, using a region of interest (ROI) methodology. Measures of reliability and precision were assessed in six ROIs using two different ROI shapes (polygonal and ellipsoidal). Results: Highly reproducible values of ADC and FA were obtained with the polygonal method on intra-rater (coefficients of variation ≤ 2.7%) and inter-rater (coefficients of variation ≤ 4.8%) reproducibility. For between-scan reproducibility, the coefficients of variation were ≤ 5.0%. Mean asymmetry indices were in the range from - 4% to 9% for FA and from - 6% to 3% for ADC. ADC showed significant negative correlation with age in 13 of 15 examined fiber tracts and FA increased significantly in three fiber tracts. Our results show that the evaluated DTI protocol is suitable for clinical application in pediatric population.

Original languageEnglish (US)
Pages (from-to)733-742
Number of pages10
Issue number2
StatePublished - Jan 15 2007


  • Apparent diffusion coefficient
  • Brain maturation
  • Children
  • Diffusion tensor imaging
  • Fractional anisotropy
  • Hemispheric differences
  • Reproducibility

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience


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