TY - JOUR
T1 - Diffusion tensor imaging in a child with hypertrophic olivary degeneration
AU - Meoded, Avner
AU - Poretti, Andrea
AU - Ilica, A. Turan
AU - Perez, Randall
AU - Jallo, George
AU - Burger, Peter C.
AU - Huisman, Thierry A.G.M.
AU - Izbudak, Izlem
PY - 2013/8
Y1 - 2013/8
N2 - Hypertrophic olivary degeneration (HOD) is caused by disruptive lesions affecting components of the Guillain-Mollaret triangle (GMT). We present conventional magnetic resonance and diffusion tensor imaging (DTI) findings in a 6-year-old girl with HOD after surgery for a midbrain pilocytic astrocytoma. To our knowledge, this is the first dedicated DTI analysis of GMT in a child with HOD in the literature. In our patient, we found higher fractional anisotropy (FA) and axial diffusivity values of the inferior olivary nucleus (ION) and lower FA, but higher radial diffusivity (RD) values of all other GMT components compared to age-matched controls. Increased FA values of the ION may be explained by increased packing of white matter fibers. However, associated hyperintense T2 signal is contradictory and the association between increased FA values and hyperintense T2 signal remains unclear. Low FA and high RD values of the other GMTcomponents likely reflect demyelination with axonal degeneration and correlate well with histopathological findings.
AB - Hypertrophic olivary degeneration (HOD) is caused by disruptive lesions affecting components of the Guillain-Mollaret triangle (GMT). We present conventional magnetic resonance and diffusion tensor imaging (DTI) findings in a 6-year-old girl with HOD after surgery for a midbrain pilocytic astrocytoma. To our knowledge, this is the first dedicated DTI analysis of GMT in a child with HOD in the literature. In our patient, we found higher fractional anisotropy (FA) and axial diffusivity values of the inferior olivary nucleus (ION) and lower FA, but higher radial diffusivity (RD) values of all other GMT components compared to age-matched controls. Increased FA values of the ION may be explained by increased packing of white matter fibers. However, associated hyperintense T2 signal is contradictory and the association between increased FA values and hyperintense T2 signal remains unclear. Low FA and high RD values of the other GMTcomponents likely reflect demyelination with axonal degeneration and correlate well with histopathological findings.
KW - Diffusion tensor imaging
KW - Guillain-Mollaret triangle
KW - Hypertrophic olivary degeneration
KW - Magnetic resonance imaging
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U2 - 10.1007/s12311-013-0448-0
DO - 10.1007/s12311-013-0448-0
M3 - Article
C2 - 23307661
AN - SCOPUS:84892370816
SN - 1473-4222
VL - 12
SP - 469
EP - 474
JO - Cerebellum
JF - Cerebellum
IS - 4
ER -