Diffusion rates of cell surface antigens of mouse-human heterokaryons: III. Regulation of lateral diffusion rates by calcium ions

Michael Edidin, Taiyin Wei, Louis Gotlib

Research output: Contribution to journalArticle

Abstract

In mouse-human heterokaryons, the lateral diffusion of major histocompatibility (MHC) antigens in the plasma membrane is enhanced by treatment of parent cells with ouabain. Ouabain treatment is ineffective if the medium lacks calcium ion, or if Verapamil, a blocker of calcium channels, is present. The divalent ionophore A23187 also enhances lateral diffusion of MHC antigens, to the same extent as ouabain. Like ouabain, A23187 is effective only if calcium is present in the medium. Thus it appears that increased levels of cell calcium release constraints to lateral diffusion of MHC antigens.

Original languageEnglish (US)
Pages (from-to)453-457
Number of pages5
JournalJournal of Cell Biology
Volume95
Issue number2
DOIs
StatePublished - Nov 1 1982

ASJC Scopus subject areas

  • Cell Biology

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