Diffuse pontine lesions in children with neurofibromatosis type 1: Making a case for unidentified bright objects

Shawn L. Hervey-Jumper; Nirmish Singla; Stephen S. Gebarski; Patricia Robertson; Cormac O. Maher

doi:10.1159/000355417

Diffuse pontine lesions in children with neurofibromatosis type 1: Making a case for unidentified bright objects

Shawn L. Hervey-Jumper, Nirmish Singla, Stephen S. Gebarski, Patricia Robertson, Cormac O. Maher

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Using an illustrative case of a presumed pontine unidentified bright object (UBO) with spontaneous lesion regression over 2 years, we review the importance of including UBOs in the differential diagnosis of children with confirmed or possible neurofibromatosis type 1 (NF1) who present with diffuse pontine enlargement and T2-weighted changes on MRI. Asymptomatic children with presumed NF1 and diffuse pontine lesions should not be treated with radiation and should not be biopsied. Prior reports of good prognosis associated with pontine glioma in patients with NF1 may have been unrecognized UBOs in some cases.

Original language	English (US)
Pages (from-to)	55-59
Number of pages	5
Journal	Pediatric Neurosurgery
Volume	49
Issue number	1
DOIs	https://doi.org/10.1159/000355417
State	Published - 2013
Externally published	Yes

Keywords

Glioma
Neurofibromatosis type 1
Unidentified bright object

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Surgery
Clinical Neurology

Access to Document

10.1159/000355417

Cite this

@article{670c87d1f36c47fc8f4dd23504111f85,

title = "Diffuse pontine lesions in children with neurofibromatosis type 1: Making a case for unidentified bright objects",

abstract = "Using an illustrative case of a presumed pontine unidentified bright object (UBO) with spontaneous lesion regression over 2 years, we review the importance of including UBOs in the differential diagnosis of children with confirmed or possible neurofibromatosis type 1 (NF1) who present with diffuse pontine enlargement and T2-weighted changes on MRI. Asymptomatic children with presumed NF1 and diffuse pontine lesions should not be treated with radiation and should not be biopsied. Prior reports of good prognosis associated with pontine glioma in patients with NF1 may have been unrecognized UBOs in some cases.",

keywords = "Glioma, Neurofibromatosis type 1, Unidentified bright object",

author = "Hervey-Jumper, {Shawn L.} and Nirmish Singla and Gebarski, {Stephen S.} and Patricia Robertson and Maher, {Cormac O.}",

note = "Publisher Copyright: {\textcopyright} 2013 S. Karger AG, Basel.",

year = "2013",

doi = "10.1159/000355417",

language = "English (US)",

volume = "49",

pages = "55--59",

journal = "Pediatric Neurosurgery",

issn = "1016-2291",

publisher = "S. Karger AG",

number = "1",

}

TY - JOUR

T1 - Diffuse pontine lesions in children with neurofibromatosis type 1

T2 - Making a case for unidentified bright objects

AU - Hervey-Jumper, Shawn L.

AU - Singla, Nirmish

AU - Gebarski, Stephen S.

AU - Robertson, Patricia

AU - Maher, Cormac O.

PY - 2013

Y1 - 2013

N2 - Using an illustrative case of a presumed pontine unidentified bright object (UBO) with spontaneous lesion regression over 2 years, we review the importance of including UBOs in the differential diagnosis of children with confirmed or possible neurofibromatosis type 1 (NF1) who present with diffuse pontine enlargement and T2-weighted changes on MRI. Asymptomatic children with presumed NF1 and diffuse pontine lesions should not be treated with radiation and should not be biopsied. Prior reports of good prognosis associated with pontine glioma in patients with NF1 may have been unrecognized UBOs in some cases.

AB - Using an illustrative case of a presumed pontine unidentified bright object (UBO) with spontaneous lesion regression over 2 years, we review the importance of including UBOs in the differential diagnosis of children with confirmed or possible neurofibromatosis type 1 (NF1) who present with diffuse pontine enlargement and T2-weighted changes on MRI. Asymptomatic children with presumed NF1 and diffuse pontine lesions should not be treated with radiation and should not be biopsied. Prior reports of good prognosis associated with pontine glioma in patients with NF1 may have been unrecognized UBOs in some cases.

KW - Glioma

KW - Neurofibromatosis type 1

KW - Unidentified bright object

UR - http://www.scopus.com/inward/record.url?scp=84891150339&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84891150339&partnerID=8YFLogxK

U2 - 10.1159/000355417

DO - 10.1159/000355417

M3 - Article

C2 - 24192157

AN - SCOPUS:84891150339

SN - 1016-2291

VL - 49

SP - 55

EP - 59

JO - Pediatric Neurosurgery

JF - Pediatric Neurosurgery

IS - 1

ER -

Diffuse pontine lesions in children with neurofibromatosis type 1: Making a case for unidentified bright objects

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this