Diffuse pontine lesions in children with neurofibromatosis type 1: Making a case for unidentified bright objects

Shawn L. Hervey-Jumper, Nirmish Singla, Stephen S. Gebarski, Patricia Robertson, Cormac O. Maher

Research output: Contribution to journalArticlepeer-review

Abstract

Using an illustrative case of a presumed pontine unidentified bright object (UBO) with spontaneous lesion regression over 2 years, we review the importance of including UBOs in the differential diagnosis of children with confirmed or possible neurofibromatosis type 1 (NF1) who present with diffuse pontine enlargement and T2-weighted changes on MRI. Asymptomatic children with presumed NF1 and diffuse pontine lesions should not be treated with radiation and should not be biopsied. Prior reports of good prognosis associated with pontine glioma in patients with NF1 may have been unrecognized UBOs in some cases.

Original languageEnglish (US)
Pages (from-to)55-59
Number of pages5
JournalPediatric Neurosurgery
Volume49
Issue number1
DOIs
StatePublished - Dec 2013
Externally publishedYes

Keywords

  • Glioma
  • Neurofibromatosis type 1
  • Unidentified bright object

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery
  • Clinical Neurology

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