Diffuse metabolic abnormalities in reversible posterior leukoencephalopathy syndrome

Florian S. Eichler, Paul Wang, Robert J. Wityk, Norman J. Beauchamp, Peter B. Barker

Research output: Contribution to journalArticlepeer-review


Two cases of reversible posterior leukoencephalopathy syndrome were examined with proton MR spectroscopic imaging. Widespread metabolic abnormalities, consisting of increased choline and creatine levels and mildly decreased N-acetylaspartate, occurred in regions with both normal and abnormal MR imaging appearances. In one case for which proton MR spectroscopic imaging follow-up was available, all metabolite levels had returned to normal by 2 months. Proton MR spectroscopic imaging may be helpful for the diagnosis and investigation of the underlying pathophysiology of reversible posterior leukoencephalopathy syndrome.

Original languageEnglish (US)
Pages (from-to)833-837
Number of pages5
JournalAmerican Journal of Neuroradiology
Issue number5
StatePublished - May 28 2002

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology


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