Diffuse fasciitis with eosinophilia developing after local irradiation for breast cancer

Noëlle S. Sherber, Fredrick Wigley, Stephen A. Paget

Research output: Contribution to journalArticle

Abstract

This case describes a patient who developed diffuse fasciitis with eosinophilia (DFE) after an exaggerated local response to radiation following excision of a lymph node-negative breast cancer. Our patient's fasciitis was diffuse, involving both upper and lower extremities and the trunk at sites distant from the irradiation and tumor site. The fasciitis progressed after curative excision of the breast cancer rather than concurrently with active breast cancer and persisted despite therapy; there was no tumor reoccurrence. With three published cases linking localized eosinophilic fasciitis with breast cancer, and with the literature suggesting that DFE commonly presents after a traumatic trigger, the possibility that radiation therapy for breast cancer could be one such trigger is an important insight for clinicians treating the many patients who undergo breast cancer treatment each year.

Original languageEnglish (US)
Pages (from-to)729-732
Number of pages4
JournalClinical Rheumatology
Volume28
Issue number6
DOIs
StatePublished - 2009

Fingerprint

Fasciitis
Eosinophilia
Breast Neoplasms
Lymph Node Excision
Lower Extremity
Neoplasms
Radiotherapy
Radiation
Therapeutics

Keywords

  • Diffuse fasciitis with eosinophilia

ASJC Scopus subject areas

  • Rheumatology

Cite this

Diffuse fasciitis with eosinophilia developing after local irradiation for breast cancer. / Sherber, Noëlle S.; Wigley, Fredrick; Paget, Stephen A.

In: Clinical Rheumatology, Vol. 28, No. 6, 2009, p. 729-732.

Research output: Contribution to journalArticle

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