Diffuse enkephalin innervation from caudate to globus pallidus

Fernando M A Correa, Robert B. Innis, Lynda D Hester, Solomon H Snyder

Research output: Contribution to journalArticle

Abstract

The source of enkephalin in neuronal terminals of the rat globus pallidus was evaluated with electrolytic and knife cut lesions. Straight knife cuts medial to the globus pallidus or a curved knife cut just below the corpus callosum do not reduce immunofluorescence staining in the globus pallidus, indicating that cerebral cortex is not a major source of pallidal enkephalin. Electrolytic lesions of dorsal and ventral portions of the globus pallidus, and even lesions which sever medial from lateral globus, fail to reduce pallidal staining, ruling out long enkephalin neurons traversing the globus. Large electrolytic lesions of the head of the caudate do decrease dorsal pallidal fluorescence, though multiple small caudate lesions are without observable effect. Large pallidal lesions elicit a build-up of enkephalin fluorescence in the caudate. These results suggest that the caudate is the sole source of pallidal enkephalin and that the innervation diffusely converges on the smaller globus pallidus.

Original languageEnglish (US)
Pages (from-to)63-68
Number of pages6
JournalNeuroscience Letters
Volume25
Issue number1
DOIs
StatePublished - Aug 7 1981

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Globus Pallidus
Enkephalins
Fluorescence
Staining and Labeling
Corpus Callosum
Cerebral Cortex
Fluorescent Antibody Technique
Neurons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Diffuse enkephalin innervation from caudate to globus pallidus. / Correa, Fernando M A; Innis, Robert B.; Hester, Lynda D; Snyder, Solomon H.

In: Neuroscience Letters, Vol. 25, No. 1, 07.08.1981, p. 63-68.

Research output: Contribution to journalArticle

Correa, Fernando M A ; Innis, Robert B. ; Hester, Lynda D ; Snyder, Solomon H. / Diffuse enkephalin innervation from caudate to globus pallidus. In: Neuroscience Letters. 1981 ; Vol. 25, No. 1. pp. 63-68.
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