Diffuse crescentic glomerulonephritis in bacterial endocarditis

Sujatha Kannan, Tej K. Mattoo

Research output: Contribution to journalArticlepeer-review

Abstract

Renal involvement is common in patients with bacterial endocarditis. The most common bacteria are staphylococci and streptococci, and the commonest renal histopathological lesion is a diffuse proliferative and exudative type of glomerulonephritis. Very rarely, patients may present with an extensive glomerular epithelial crescent formation with a rapid deterioration in the renal function. This study reviews the published literature on diffuse crescentic glomerulonephritis in bacterial endocarditis and reports a 24-year-old male patient with endocarditis due to Capnocytophagia species, a gram-negative facultative anaerobic bacillus, which normally inhabits the oral cavity. Appropriate antibiotic therapy is essential to eradicate the infection. A brief course of corticosteroid therapy may be helpful in those with deteriorating renal function. Plasmapheresis may be useful in those with persistent hypocomplementemia, increased circulating immune complexes, and a progressive deterioration in the renal function. Removal of vegetation or valve replacement may be necessary. Prognosis is generally good.

Original languageEnglish (US)
Pages (from-to)423-428
Number of pages6
JournalPediatric Nephrology
Volume16
Issue number5
DOIs
StatePublished - May 1 2001
Externally publishedYes

Keywords

  • Bacterial endocarditis
  • Corticosteroids
  • Crescentic glomerulonephritis
  • Renal failure

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

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