TY - JOUR
T1 - Diffuse corneal clouding in siblings with fetal alcohol syndrome
AU - Edward, D. P.
AU - Li, J.
AU - Sawaguchi, S.
AU - Sugar, J.
AU - Yue, B. Y.J.T.
AU - Tso, M. O.M.
N1 - Funding Information:
Accepted for publication Dec. 7, 1992. From the Georgiana Dvorak Theobald Ophthalmic Pathology Laboratory, Department of Ophthalmology and Visual Sciences, Lions of Illinois Eye Research Institute, UIC Eye Center, University of Illinois at Chicago College of Medicine, Chicago, Illinois. This study was supported in part by core grant EYOI792 from the National Eye Institute, Bethesda, Maryland; gifts from the Lions of Illinois Foundation, Maywood, Illinois; an unrestricted research grant from Research to Prevent Blindness, Inc., New York, New York (UIC Eye Center); gifts from the Clifford Sawyer Estate; and a grant from the McGraw Foundation, Arlington Heights, Illinois (Dr. Tso). Reprint requests to Mark O. M. Tso, M.D., Georgiana Dvorak Theobald Ophthalmic Pathology Laboratory, Department of Ophthalmology and Visual Sciences, Lions of Illinois Eye Research Institute, UIC Eye Center, University of Illinois at Chicago College of Medicine, 1855 W. Taylor s-, Chicago, IL 60612.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1993
Y1 - 1993
N2 - Three of four siblings born to parents with a history of heavy alcohol abuse had bilateral diffusely cloudy corneas at birth. These three siblings, who had mild systemic features of fetal alcohol syndrome, underwent corneal transplantations, and their specimens were examined by light and electron microscopy. Histologically, the alterations in Bowman's layer ranged from thickening to total loss. There were varying degrees of corneal stromal edema. The unique pathologic feature in the corneas was the anomaly of the anterior banded zone of Descemet's membrane, which was either absent, poorly formed, or thinned in the central and peripheral cornea. The corneal endothelium was attenuated or multilayered. The diffuse clouding and the range of histologic abnormalities in the corneas might be related to the maternal alcohol abuse.
AB - Three of four siblings born to parents with a history of heavy alcohol abuse had bilateral diffusely cloudy corneas at birth. These three siblings, who had mild systemic features of fetal alcohol syndrome, underwent corneal transplantations, and their specimens were examined by light and electron microscopy. Histologically, the alterations in Bowman's layer ranged from thickening to total loss. There were varying degrees of corneal stromal edema. The unique pathologic feature in the corneas was the anomaly of the anterior banded zone of Descemet's membrane, which was either absent, poorly formed, or thinned in the central and peripheral cornea. The corneal endothelium was attenuated or multilayered. The diffuse clouding and the range of histologic abnormalities in the corneas might be related to the maternal alcohol abuse.
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U2 - 10.1016/S0002-9394(14)74451-4
DO - 10.1016/S0002-9394(14)74451-4
M3 - Article
C2 - 8470721
AN - SCOPUS:0027481419
VL - 115
SP - 484
EP - 493
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
IS - 4
ER -