Differing risk factors for cerebral palsy in the presence of mental retardation and epilepsy

Carla Arpino, Paolo Curatolo, Maria Antonietta Stazi, Alda Pellegri, David Vlahov

    Research output: Contribution to journalArticle

    Abstract

    Whether the combined diagnosis of cerebral palsy with mental retardation or with mental retardation and epilepsy reflects more severe manifestations of the spectrum of cerebral palsy, or whether these conditions reflect overlapping outcomes related to different exposure, remains an open question. At two centers, in Rome and Conegliano, Italy, 51 children with combined cerebral palsy, mental retardation, and epilepsy, 31 children with both cerebral palsy and mental retardation, and 48 with cerebral palsy alone were identified and examined, and their mothers interviewed. The triple diagnosis group was significantly more likely than the other two groups to have a history of neonatal convulsions and a history of epilepsy in first-degree relatives, but less likely to have a mother's age at delivery greater than 33 years, a birthweight less than 1500 g, or gestational age less than 32 weeks. The dual diagnosis group was more likely than the other two groups to have maternal education of less than 8 years. These data suggest the possibility of different etiopathogenetic pathways for various presentations of cerebral palsy.

    Original languageEnglish (US)
    Pages (from-to)151-155
    Number of pages5
    JournalJournal of child neurology
    Volume14
    Issue number3
    DOIs
    StatePublished - Mar 1999

    ASJC Scopus subject areas

    • Pediatrics, Perinatology, and Child Health
    • Clinical Neurology

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