Four inbred strains differed greatly in their response to a standard inoculation of rat thyroid extract with complete Freund's adjuvant and pertussis vaccine. Strains HO and AU, both Ag-B5, developed only minimal lesions, although AU rats had a high titer of circulating antibodies to thyroid antigens. AO rats (Ag-B2) and DA rats (Ag-B4) showed more severe thyroiditis. AO rats had high titers of antibody while the DA strain had only moderate titers.
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