Differing responses of inbred rat strains in experimental autoimmune thyroiditis

Noel R. Rose

doi:10.1016/0008-8749(75)90064-7

Differing responses of inbred rat strains in experimental autoimmune thyroiditis

Noel R. Rose

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Four inbred strains differed greatly in their response to a standard inoculation of rat thyroid extract with complete Freund's adjuvant and pertussis vaccine. Strains HO and AU, both Ag-B5, developed only minimal lesions, although AU rats had a high titer of circulating antibodies to thyroid antigens. AO rats (Ag-B2) and DA rats (Ag-B4) showed more severe thyroiditis. AO rats had high titers of antibody while the DA strain had only moderate titers.

Original language	English (US)
Pages (from-to)	360-364
Number of pages	5
Journal	Cellular Immunology
Volume	18
Issue number	2
DOIs	https://doi.org/10.1016/0008-8749(75)90064-7
State	Published - Aug 1975
Externally published	Yes

ASJC Scopus subject areas

Immunology

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title = "Differing responses of inbred rat strains in experimental autoimmune thyroiditis",

abstract = "Four inbred strains differed greatly in their response to a standard inoculation of rat thyroid extract with complete Freund's adjuvant and pertussis vaccine. Strains HO and AU, both Ag-B5, developed only minimal lesions, although AU rats had a high titer of circulating antibodies to thyroid antigens. AO rats (Ag-B2) and DA rats (Ag-B4) showed more severe thyroiditis. AO rats had high titers of antibody while the DA strain had only moderate titers.",

author = "Rose, {Noel R.}",

note = "Funding Information: The author wishes to acknowledge the hospitality and encouragement of Prof. James L. Gowans and the technical assistance of Mr. Steven Simmonds. He received support from the Buswell Foundation and NIH Research Grant CA02357 from the National Cancer Institute.",

year = "1975",

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N1 - Funding Information: The author wishes to acknowledge the hospitality and encouragement of Prof. James L. Gowans and the technical assistance of Mr. Steven Simmonds. He received support from the Buswell Foundation and NIH Research Grant CA02357 from the National Cancer Institute.

PY - 1975/8

Y1 - 1975/8

N2 - Four inbred strains differed greatly in their response to a standard inoculation of rat thyroid extract with complete Freund's adjuvant and pertussis vaccine. Strains HO and AU, both Ag-B5, developed only minimal lesions, although AU rats had a high titer of circulating antibodies to thyroid antigens. AO rats (Ag-B2) and DA rats (Ag-B4) showed more severe thyroiditis. AO rats had high titers of antibody while the DA strain had only moderate titers.

AB - Four inbred strains differed greatly in their response to a standard inoculation of rat thyroid extract with complete Freund's adjuvant and pertussis vaccine. Strains HO and AU, both Ag-B5, developed only minimal lesions, although AU rats had a high titer of circulating antibodies to thyroid antigens. AO rats (Ag-B2) and DA rats (Ag-B4) showed more severe thyroiditis. AO rats had high titers of antibody while the DA strain had only moderate titers.

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Differing responses of inbred rat strains in experimental autoimmune thyroiditis

Abstract

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