Differing responses of inbred rat strains in experimental autoimmune thyroiditis

Noel R. Rose

Research output: Contribution to journalArticlepeer-review

Abstract

Four inbred strains differed greatly in their response to a standard inoculation of rat thyroid extract with complete Freund's adjuvant and pertussis vaccine. Strains HO and AU, both Ag-B5, developed only minimal lesions, although AU rats had a high titer of circulating antibodies to thyroid antigens. AO rats (Ag-B2) and DA rats (Ag-B4) showed more severe thyroiditis. AO rats had high titers of antibody while the DA strain had only moderate titers.

Original languageEnglish (US)
Pages (from-to)360-364
Number of pages5
JournalCellular Immunology
Volume18
Issue number2
DOIs
StatePublished - Aug 1975

ASJC Scopus subject areas

  • Immunology

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