Differentiation of neuromyelitis optica from multiple sclerosis on spinal magnetic resonance imaging

Saurabh Lalan, Majid Khan, Bruce Schlakman, Alan Penman, Joseph Gatlin, Robert Herndon

Research output: Contribution to journalArticle

Abstract

In order to examine the accuracy of magnetic resonance imaging (MRI)-based diagnosis of neuromyelitis optica (NMO) versus multiple sclerosis (MS), we performed a retrospective, rater-blinded review of 29 cases of NMO and 30 cases of MS using the criteria of long (more than three vertebral levels), continuous lesions with a central cord location for NMO and more peripheral and patchy lesions for MS. Using these criteria, two raters were able to distinguish the two conditions with a good degree of confidence, particularly when the imaging was performed at the time of an acute cord attack. The sensitivity and specificity for diagnosis of NMO were 86.2% and 93.3%, respectively, for Rater A and 96.4% and 78.6%, respectively, for Rater B, with a kappa value of 0.72. Thus there are significant differences in lesion characteristics that allow the distinction on spinal cord imaging between MS and NMO with a moderately high degree of confidence. The location of the lesion as evident on MRI of the spine can be regarded as a distinguishing diagnostic feature between MS and NMO.

Original languageEnglish (US)
Pages (from-to)209-214
Number of pages6
JournalInternational Journal of MS Care
Volume14
Issue number4
DOIs
StatePublished - Dec 1 2012
Externally publishedYes

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Neuromyelitis Optica
Multiple Sclerosis
Magnetic Resonance Imaging
Spinal Cord
Spine
Sensitivity and Specificity

ASJC Scopus subject areas

  • Clinical Neurology
  • Advanced and Specialized Nursing

Cite this

Differentiation of neuromyelitis optica from multiple sclerosis on spinal magnetic resonance imaging. / Lalan, Saurabh; Khan, Majid; Schlakman, Bruce; Penman, Alan; Gatlin, Joseph; Herndon, Robert.

In: International Journal of MS Care, Vol. 14, No. 4, 01.12.2012, p. 209-214.

Research output: Contribution to journalArticle

Lalan, Saurabh ; Khan, Majid ; Schlakman, Bruce ; Penman, Alan ; Gatlin, Joseph ; Herndon, Robert. / Differentiation of neuromyelitis optica from multiple sclerosis on spinal magnetic resonance imaging. In: International Journal of MS Care. 2012 ; Vol. 14, No. 4. pp. 209-214.
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