Differentiation of delta and mu opiate receptor localizations by light microscopic autoradiography

R. R. Goodman, S. H. Snyder, M. J. Kuhar, W. S. Young

Research output: Contribution to journalArticlepeer-review

Abstract

We have observed two discrete populations of opiate receptors that are differently localized in rat brain. Morphine-like (mu) receptors, labeled by 125I-labeled [D-Ala-2MePhe4Met(O)5-ol]enkephalin, are concentrated selectively in lamina IV of the cerebral cortex, certain thalamic nuclei, and the periaqueductal grey, while delta receptors, labeled by 125I-labeled [D-Ala2D-Leu5]enkephalin, are more diffused, having high densities in cerebral cortex, corpus striatum, amygdala, and olfactory tubercle. Because of similarities in their localizations, we propose that mu and delta receptors are respectively the physiologic receptors for [Met]- and [Leu]enkephalin neurons. These distributions reflect the different physiological functions attributed to mu and delta receptors and thus represent discrete functions of [Met]- and [Leu]enkephalin neurons.

Original languageEnglish (US)
Pages (from-to)6239-6243
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume77
Issue number10 II
DOIs
StatePublished - 1980

ASJC Scopus subject areas

  • General

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