Differentiation between B cells, T cells, and histiocytes in melanocytic lesions: Primary and metastatic melanoma and halo and giant pigmented nevi

Richard L. Edelson, Vincent J. Hearing, A. Lee Dellon, Michael Frank, Edmond K. Edelson, Ira Green

Research output: Contribution to journalArticlepeer-review

Abstract

Membrane properties of infiltrating mononuclear cells in melanocytic lesions were studied. In frozen sections of six primary melanomas and six halo nevi, the infiltrating cells lacked C3 receptors characteristic of B cells and IgG receptors characteristic of histiocytes. Viable infiltrating cells extracted from two primary melanomas formed rosettes with sheep erythrocytes, providing direct evidence of their T cell identity. In contrast, the majority of cells infiltrating melanoma metastases in four patients were identified as histiocytes by their IgG receptors and ultrastructural appearance. Focal aggregates of B cells and plasma cells were found in a giant pigmented nevus in areas of disrupted nevus cells. This suggests a B cell mediated response against nevus-associated antigens, possibly involving antibody dependent target cell lysis. It appears that a spectrum of cellular reactions to melanocytic lesions occurs in vivo and that the type of infiltrating mononuclear cell is related to the type of lesion.

Original languageEnglish (US)
Pages (from-to)557-568
Number of pages12
JournalClinical Immunology and Immunopathology
Volume4
Issue number4
DOIs
StatePublished - Nov 1975
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

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