Differentiating lower motor neuron syndromes

Nidhi Garg, Susanna B. Park, Steve Vucic, Con Yiannikas, Judy Spies, James Howells, William Huynh, José M. Matamala, Arun V. Krishnan, John D. Pollard, David R. Cornblath, Mary M. Reilly, Matthew C. Kiernan

Research output: Contribution to journalReview articlepeer-review


Lower motor neuron (LMN) syndromes typically present with muscle wasting and weakness and may arise from pathology affecting the distal motor nerve up to the level of the anterior horn cell. A variety of hereditary causes are recognised, including spinal muscular atrophy, distal hereditary motor neuropathy and LMN variants of familial motor neuron disease. Recent genetic advances have resulted in the identification of a variety of disease-causing mutations. Immune-mediated disorders, including multifocal motor neuropathy and variants of chronic inflammatory demyelinating polyneuropathy, account for a proportion of LMN presentations and are important to recognise, as effective treatments are available. The present review will outline the spectrum of LMN syndromes that may develop in adulthood and provide a framework for the clinician assessing a patient presenting with predominantly LMN features.

Original languageEnglish (US)
Pages (from-to)474-483
Number of pages10
JournalJournal of Neurology, Neurosurgery and Psychiatry
Issue number6
StatePublished - Jun 1 2017



ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health

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