Differentiating hemodynamic compromise by the OEF response to acetazolamide in occlusive vascular disease

Edwin M. Nemoto, Howard Yonas, Hiroto Kuwabara, Ronda Pindzola, Donald Sashin, Yuefang Chang, Tudor Jovin, James Gebel, Maxim D. Hammer, Lawrence Wechsler

Research output: Contribution to journalArticle

Abstract

Identification of increased stroke risk in a population of symptomatic patients with occlusive vascular disease (OVD) is presently accomplished by measurement of oxygen extraction fraction (OEF) or cerebrovascular reserve (CVR). However, many regions identified by compromised CVR are not identified by OEF. Our aim was to determine whether the response of OEF to acetazolamide, namely, oxygen extraction fraction response (OEFR) would identify those hemispheres in hemodynamic compromise with normal OEF. Nine patients symptomatic with transient ischemic attacks and strokes, and with occlusive vascular disease were studied. Anatomical MRI scans and T2-weighted images were used to identify and grade subcortical white matter infarcts. PET cerebral blood flow (CBF) and OEF were measured after acetazolamide. The relationship between CVR and oxygen extraction fraction response (OEFR) showed that positive OEFR occurred after acetazolamide despite normal baseline OEF values. The two hemispheres with positive OEFR were also associated with severe (> 3 cm) subcortical white matter infarcts. We found that the OEFR was highly correlated with CVR and identified hemispheres that were hemodynamically compromised despite normal baseline OEF.

Original languageEnglish (US)
Pages (from-to)135-141
Number of pages7
JournalAdvances in Experimental Medicine and Biology
Volume566
DOIs
StatePublished - 2005
Externally publishedYes

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Acetazolamide
Hemodynamics
Vascular Diseases
Oxygen
Cerebrovascular Circulation
Stroke
Transient Ischemic Attack
Blood

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Differentiating hemodynamic compromise by the OEF response to acetazolamide in occlusive vascular disease. / Nemoto, Edwin M.; Yonas, Howard; Kuwabara, Hiroto; Pindzola, Ronda; Sashin, Donald; Chang, Yuefang; Jovin, Tudor; Gebel, James; Hammer, Maxim D.; Wechsler, Lawrence.

In: Advances in Experimental Medicine and Biology, Vol. 566, 2005, p. 135-141.

Research output: Contribution to journalArticle

Nemoto, EM, Yonas, H, Kuwabara, H, Pindzola, R, Sashin, D, Chang, Y, Jovin, T, Gebel, J, Hammer, MD & Wechsler, L 2005, 'Differentiating hemodynamic compromise by the OEF response to acetazolamide in occlusive vascular disease', Advances in Experimental Medicine and Biology, vol. 566, pp. 135-141. https://doi.org/10.1007/0-387-26206-7_19
Nemoto, Edwin M. ; Yonas, Howard ; Kuwabara, Hiroto ; Pindzola, Ronda ; Sashin, Donald ; Chang, Yuefang ; Jovin, Tudor ; Gebel, James ; Hammer, Maxim D. ; Wechsler, Lawrence. / Differentiating hemodynamic compromise by the OEF response to acetazolamide in occlusive vascular disease. In: Advances in Experimental Medicine and Biology. 2005 ; Vol. 566. pp. 135-141.
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AU - Sashin, Donald

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