Differentiating Alzheimer's disease and frontotemporal dementia: Receiver operator characteristic curve analysis of four rating scales

W. Michael Hooten, Constantine G. Lyketsos

Research output: Contribution to journalArticle


Alzheimer's disease and frontotemporal dementia are two of the most common types of degenerative dementia. In conjunction with a complete neuropsychiatric examination, the Executive Interview®, Mini-Mental State Exam, Alzheimer's Disease Scale, Pick's Disease Scale and the Informant-Based Questionnaire have been used to distinguish between these two disorders on clinical grounds. In a review of two studies, scores from these rating scales are subjected to receiver operator characteristic curve analysis to determine the cut-off value for each scale which yields the highest sensitivity and specificity with regard to differentiating between Alzheimer's disease and frontotemporal dementia. Finally, the Informant-Based Questionnaire is discussed and compared to each rating scale to demonstrate the important features and limitations of each.

Original languageEnglish (US)
Pages (from-to)164-174
Number of pages11
JournalDementia and Geriatric Cognitive Disorders
Issue number3
StatePublished - May 1 1998



  • Alzheimer's disease
  • Diagnosis
  • Frontotemporal dementia
  • Receiver operator characteristic analysis
  • Sensitivity
  • Specificity

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cognitive Neuroscience
  • Psychiatry and Mental health

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