Differentiated (simplex) vulvar intraepithelial neoplasia: A case report and review of the literature

Janis M. Taube, Joanna Badger, Christina S. Kong, Soheil S. Dadras

Research output: Contribution to journalArticlepeer-review


Differentiated (simplex) vulvar intraepithelial neoplasia (VIN) is an uncommon variant of VIN characterized by highly differentiated morphology, making it a potential diagnostic pitfall. It may arise in the background of lichen sclerosus, and unlike most VIN, is not causally associated with human papilloma virus infection. It occurs in an older demographic and is thought to be the precursor of aggressive, invasive vulvar squamous cell carcinoma. For this reason, the timely and accurate diagnosis of this unusual lesion is crucial. The clinical and histologic features of a case of a 70-year-old woman with newly diagnosed differentiated (simplex) VIN arising in a background of long-standing lichen sclerosus is reported, and the historic aspects, current terminology, and diagnostic criteria of differentiated (simplex) VIN are reviewed.

Original languageEnglish (US)
Pages (from-to)e27-e30
JournalAmerican Journal of Dermatopathology
Issue number3
StatePublished - May 1 2011


  • differentiated VIN
  • lichen sclerosus
  • simplex VIN
  • vulva

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dermatology

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