TY - GEN
T1 - Differentially branched ester amine quadpolymers with amphiphilic and ph sensitive properties for efficient nucleic acid delivery
AU - Wilson, David R.
AU - Rui, Yuan
AU - Siddiq, Kamran
AU - Routkevitch, Denis
AU - Green, Jordan
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Statement of Purpose: Effective cytosolic delivery of nucleic acids using non-viral vectors remains challenging due to their high net negative charge, susceptibility to nuclease degradation and high molecular weight. Here we demonstrate definitive improvements in polymer efficacy and efficiency for delivery of plasmid DNA over previous generation optimized materials by modulating degree of polymer branching, hydrophobicity, pH sensitivity and specific primary, secondary and tertiary amine content.
AB - Statement of Purpose: Effective cytosolic delivery of nucleic acids using non-viral vectors remains challenging due to their high net negative charge, susceptibility to nuclease degradation and high molecular weight. Here we demonstrate definitive improvements in polymer efficacy and efficiency for delivery of plasmid DNA over previous generation optimized materials by modulating degree of polymer branching, hydrophobicity, pH sensitivity and specific primary, secondary and tertiary amine content.
UR - http://www.scopus.com/inward/record.url?scp=85065404322&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85065404322&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85065404322
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
BT - Society for Biomaterials Annual Meeting and Exposition 2019
PB - Society for Biomaterials
T2 - 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Y2 - 3 April 2019 through 6 April 2019
ER -