Differentially branched ester amine quadpolymers with amphiphilic and ph sensitive properties for efficient nucleic acid delivery

David R. Wilson, Yuan Rui, Kamran Siddiq, Denis Routkevitch, Jordan Green

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Effective cytosolic delivery of nucleic acids using non-viral vectors remains challenging due to their high net negative charge, susceptibility to nuclease degradation and high molecular weight. Here we demonstrate definitive improvements in polymer efficacy and efficiency for delivery of plasmid DNA over previous generation optimized materials by modulating degree of polymer branching, hydrophobicity, pH sensitivity and specific primary, secondary and tertiary amine content.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

Fingerprint

Nucleic acids
Nucleic Acids
Amines
Esters
Polymers
Hydrophobicity
Hydrophobic and Hydrophilic Interactions
Plasmids
DNA
Molecular Weight
Molecular weight
Degradation

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

Cite this

Wilson, D. R., Rui, Y., Siddiq, K., Routkevitch, D., & Green, J. (2019). Differentially branched ester amine quadpolymers with amphiphilic and ph sensitive properties for efficient nucleic acid delivery. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.

Differentially branched ester amine quadpolymers with amphiphilic and ph sensitive properties for efficient nucleic acid delivery. / Wilson, David R.; Rui, Yuan; Siddiq, Kamran; Routkevitch, Denis; Green, Jordan.

Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Wilson, DR, Rui, Y, Siddiq, K, Routkevitch, D & Green, J 2019, Differentially branched ester amine quadpolymers with amphiphilic and ph sensitive properties for efficient nucleic acid delivery. in Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, vol. 40, Society for Biomaterials, 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence, Seattle, United States, 4/3/19.
Wilson DR, Rui Y, Siddiq K, Routkevitch D, Green J. Differentially branched ester amine quadpolymers with amphiphilic and ph sensitive properties for efficient nucleic acid delivery. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials. 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).
Wilson, David R. ; Rui, Yuan ; Siddiq, Kamran ; Routkevitch, Denis ; Green, Jordan. / Differentially branched ester amine quadpolymers with amphiphilic and ph sensitive properties for efficient nucleic acid delivery. Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).
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