Differential Vascularity in Genetic and Nonhereditary Heterotopic Ossification

Alisha D. Ware, Niambi Brewer, Carolyn Meyers, Carol D Morris, Edward F McCarthy, Eileen M. Shore, Aaron James

Research output: Contribution to journalArticle

Abstract

Introduction. Nonhereditary heterotopic ossification (NHO) is a common complication of trauma. Progressive osseous heteroplasia (POH) and fibrodysplasia ossificans progressiva (FOP) are rare genetic causes of heterotopic bone. In this article, we detail the vascular patterning associated with genetic versus NHO. Methods. Vascular histomorphometric analysis was performed on patient samples from POH, FOP, and NHO. Endpoints for analysis included blood vessel (BV) number, area, density, size, and wall thickness. Results. Results demonstrated conserved temporal dynamic changes in vascularity across all heterotopic ossification lesions. Immature areas had the highest BV number, while the more mature foci had the highest BV area. Most vascular parameters were significantly increased in genetic as compared with NHO. Discussion. In sum, both genetic and NHO show temporospatial variation in vascularity. These findings suggest that angiogenic pathways are potential therapeutic targets in both genetic and nonhereditary forms of heterotopic ossification.

Original languageEnglish (US)
JournalInternational journal of surgical pathology
DOIs
StatePublished - Jan 1 2019

Fingerprint

Heterotopic Ossification
Blood Vessels
Myositis Ossificans
Bone and Bones
Wounds and Injuries

Keywords

  • angiogenesis
  • fibrodysplasia ossificans progressive
  • heterotopic bone
  • heterotopic ossification
  • progressive heterotopic ossification

ASJC Scopus subject areas

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this

Differential Vascularity in Genetic and Nonhereditary Heterotopic Ossification. / Ware, Alisha D.; Brewer, Niambi; Meyers, Carolyn; Morris, Carol D; McCarthy, Edward F; Shore, Eileen M.; James, Aaron.

In: International journal of surgical pathology, 01.01.2019.

Research output: Contribution to journalArticle

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