Differential sulphation of chondroitins in murine T and B lymphocytes and lymphoma cells

Christopher C. Rider, Gerald Warren Hart

Research output: Contribution to journalArticle

Abstract

Splenic B and T lymphocytes metabolically labelled in vitro with [35S]-H2SO4 show differential sulphation of chondroitin sulphate, the major sulphated glycosaminoglycan in both cell-retained and secreted fractions. In B cells, 6-O-sulphation is more abundant than 4-O-sulphation, whereas in T cells sulphation occurs predominantly in the 4-O-position. The murine lymphoma lines AKTB-1b and EL-4, of B and T origin respectively, show even more marked differences. AKTB-1b follows the pattern of normal B cells, whilst in EL-4 only chondroitin 4-sulphate is synthesized.

Original languageEnglish (US)
Pages (from-to)963-967
Number of pages5
JournalMolecular Immunology
Volume24
Issue number9
DOIs
StatePublished - 1987

ASJC Scopus subject areas

  • Molecular Biology
  • Immunology

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