Differential stimulation of PKC phosphorylation of potassium channels by ZIP1 and ZIP2

Jianping Gong, Jia Xu, Magdalena Bezanilla, Rika Van Huizen, Rachel Derin, Min Li

Research output: Contribution to journalArticle

Abstract

Targeting of protein modification enzymes is a key biochemical step to achieve specific and effective posttranslational modifications. Two alternatively spliced ZIP1 and ZIP2 proteins are described, which bind to both Kvβ2 subunits of potassium channel and protein kinase C (PKC) ζ, thereby acting as a physical link in the assembly of PKCζ-ZIP-potassium channel complexes. ZIP1 and ZIP2 differentially stimulate phosphorylation of Kvβ2 by PKCζ. They also interact to form heteromultimers, which allows for a hybrid stimulatory activity to PKCζ. Finally, ZIP1 and ZIP2 coexist in the same cell type and are elevated differentially by neurotrophic factors. These results provide a mechanism for specificity and regulation of PKCζ-targeted phosphorylation.

Original languageEnglish (US)
Pages (from-to)1565-1569
Number of pages5
JournalScience
Volume285
Issue number5433
DOIs
StatePublished - Sep 3 1999

ASJC Scopus subject areas

  • General

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    Gong, J., Xu, J., Bezanilla, M., Van Huizen, R., Derin, R., & Li, M. (1999). Differential stimulation of PKC phosphorylation of potassium channels by ZIP1 and ZIP2. Science, 285(5433), 1565-1569. https://doi.org/10.1126/science.285.5433.1565