Differential serum cytokine responses to inactivated and live attenuated seasonal influenza vaccines

Amritha Ramakrishnan, Keri Althoff, Joseph A. Lopez, Christian L. Coles, Jay Bream

Research output: Contribution to journalArticle

Abstract

Despite vaccine efforts, influenza outbreaks pose a significant threat to global public health. There are two commercially available seasonal influenza vaccines in the United States: the trivalent inactivated vaccine (TIV), delivered parenterally, and the live attenuated influenza vaccine (LAIV), delivered intranasally. Although both vaccines are generally efficacious, the immunologic mechanisms which contribute to protective immunity are incompletely understood. Thus, we investigated the protracted effects of TIV and LAIV on serum cytokine profiles at 14 and 28 days post-vaccination (when antibody titers are peak) in healthy adults over two influenza seasons. Vaccination with TIV was associated with a small, yet significant, decrease in the levels of both IL-8 and TNF-α at 14 and 28 days post-vaccination. LAIV, however, had no impact on serum cytokine levels. Similarly, analysis of serum antibody titers indicated that TIV recipients had a significantly higher sero-response rate compared to LAIV recipients, as has been previously shown. Finally, we examined the relationship between baseline serum cytokine levels and antibody responses to TIV (LAIV recipients were excluded due to the poor sero-response rate). Interestingly, in TIV recipients pre-vaccination levels of IL-8 were higher in sero-responders compared to non-responders. Collectively, these data suggest that cytokines may influence vaccine outcomes and indicate that parenteral immunization with TIV induces a sustained, systemic cytokine response which lasts for weeks.

Original languageEnglish (US)
Pages (from-to)661-666
Number of pages6
JournalCytokine
Volume60
Issue number3
DOIs
StatePublished - Dec 2012

Fingerprint

Attenuated Vaccines
Inactivated Vaccines
Influenza Vaccines
Cytokines
Serum
Vaccination
Interleukin-8
Antibodies
Vaccines
Immunization
Public health
Human Influenza
Antibody Formation
Disease Outbreaks
Immunity
Public Health

Keywords

  • Cytokine
  • Influenza
  • Vaccine

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Hematology
  • Biochemistry
  • Molecular Biology

Cite this

Differential serum cytokine responses to inactivated and live attenuated seasonal influenza vaccines. / Ramakrishnan, Amritha; Althoff, Keri; Lopez, Joseph A.; Coles, Christian L.; Bream, Jay.

In: Cytokine, Vol. 60, No. 3, 12.2012, p. 661-666.

Research output: Contribution to journalArticle

Ramakrishnan, Amritha ; Althoff, Keri ; Lopez, Joseph A. ; Coles, Christian L. ; Bream, Jay. / Differential serum cytokine responses to inactivated and live attenuated seasonal influenza vaccines. In: Cytokine. 2012 ; Vol. 60, No. 3. pp. 661-666.
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