Differential sensitivity to midazolam discriminative-stimulus effects following self-administered versus response-independent midazolam

Research output: Contribution to journalArticle

Abstract

Interactions between the discriminative and reinforcing effects of midazolam were studied in two baboons trained to discriminate midazolam (0.32 mg/kg, IV) from saline. The midazolam generalization gradient determined after the baboons were permitted to self-administer midazolam (IV) was shifted to the left of that determined before self-administration. In contrast, the midazolam generalization gradient determined after the same doses of midazolam were delivered response-independently, but in the same order and with the same temporal pattern as during self-administration, was shifted to the right of that determined just before the response-independent phase. These data suggest that sensitivity to the discriminative-stimulus effects of a drug can be modulated by behavioral experience with that drug.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalPsychopharmacology
Volume110
Issue number1-2
DOIs
StatePublished - Jan 1 1993

Keywords

  • Baboon
  • Discrimination
  • Midazolam
  • Self-administration

ASJC Scopus subject areas

  • Pharmacology

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