Differential response to cardiac resynchronization therapy and clinical outcomes according to QRS morphology and QRS duration

Matthias Dupont, John Rickard, Bryan Baranowski, Niraj Varma, Thomas Dresing, Alaa Gabi, Michael Finucan, Wilfried Mullens, Bruce L. Wilkoff, W. H Wilson Tang

Research output: Contribution to journalArticle

Abstract

Objectives: The goal of this study was to examine the relative impact of QRS morphology and duration in echocardiographic responses to cardiac resynchronization therapy (CRT) and clinical outcomes. Background: At least one-third of all patients treated with CRT fail to derive benefit. Patients without left bundle branch block (LBBB) or patients with smaller QRS duration (QRSd) respond less or not at all to CRT. Methods: We retrospectively assessed baseline characteristics, clinical and echocardiographic response, and outcomes of all patients who received CRT at our institution between December 2003 and July 2007. Patients were stratified into 4 groups according to their baseline QRS morphology and QRSd. Results: A total of 496 patients were included in the study; 216 (43.5%) had LBBB and a QRSd

Original languageEnglish (US)
Pages (from-to)592-598
Number of pages7
JournalJournal of the American College of Cardiology
Volume60
Issue number7
DOIs
StatePublished - Aug 14 2012
Externally publishedYes

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Cardiac Resynchronization Therapy
Bundle-Branch Block

Keywords

  • cardiac resynchronization therapy
  • heart failure
  • left bundle branch block
  • QRS duration

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Differential response to cardiac resynchronization therapy and clinical outcomes according to QRS morphology and QRS duration. / Dupont, Matthias; Rickard, John; Baranowski, Bryan; Varma, Niraj; Dresing, Thomas; Gabi, Alaa; Finucan, Michael; Mullens, Wilfried; Wilkoff, Bruce L.; Tang, W. H Wilson.

In: Journal of the American College of Cardiology, Vol. 60, No. 7, 14.08.2012, p. 592-598.

Research output: Contribution to journalArticle

Dupont, M, Rickard, J, Baranowski, B, Varma, N, Dresing, T, Gabi, A, Finucan, M, Mullens, W, Wilkoff, BL & Tang, WHW 2012, 'Differential response to cardiac resynchronization therapy and clinical outcomes according to QRS morphology and QRS duration', Journal of the American College of Cardiology, vol. 60, no. 7, pp. 592-598. https://doi.org/10.1016/j.jacc.2012.03.059
Dupont, Matthias ; Rickard, John ; Baranowski, Bryan ; Varma, Niraj ; Dresing, Thomas ; Gabi, Alaa ; Finucan, Michael ; Mullens, Wilfried ; Wilkoff, Bruce L. ; Tang, W. H Wilson. / Differential response to cardiac resynchronization therapy and clinical outcomes according to QRS morphology and QRS duration. In: Journal of the American College of Cardiology. 2012 ; Vol. 60, No. 7. pp. 592-598.
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AU - Gabi, Alaa

AU - Finucan, Michael

AU - Mullens, Wilfried

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