Differential requirements for HIV-1 vif-mediated APOBEC3G degradation and RUNX1-mediated transcription by core binding factor beta

Juan Du, Ke Zhao, Yajuan Rui, Peng Li, Xiaohong Zhou, Wenyan Zhang, Xiao Fang Yu

Research output: Contribution to journalArticlepeer-review

Abstract

Core binding factor beta (CBFβ), a transcription regulator through RUNX binding, was recently reported critical for Vif function. Here, we mapped the primary functional domain important for Vif function to amino acids 15 to 126 of CBFβ. We also revealed that different lengths and regions are required for CBFβ to assist Vif or RUNX. The important interaction domains that are uniquely required for Vif but not RUNX function represent novel targets for the development of HIV inhibitors.

Original languageEnglish (US)
Pages (from-to)1906-1911
Number of pages6
JournalJournal of virology
Volume87
Issue number3
DOIs
StatePublished - Feb 2013

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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