Differential requirements for α4 integrins during fetal and adult hematopoiesis

Alicia G. Arroyo, Joy T. Yang, Helen Rayburn, Richard O. Hynes

Research output: Contribution to journalArticlepeer-review

Abstract

Mice chimeric for the expression of α4 integrins were used to dissect the roles of these receptors in development and traffic of lymphoid and myeloid cells. During fetal life, T cell development is α4 independent, but after birth further production of T cells becomes α4 dependent. Precursors for both T and B cells require α4 integrins for normal development within the bone marrow. In contrast, monocytes and natural killer cells can develop normally without α4 integrins. Thus, there are lymphocyte-specific, developmentally regulated requirements for α4 integrins in hematopoiesis in the bone marrow. We also show that α4 integrins are essential for T cell homing to Peyer's patches, but not to other secondary lymphoid organs, including spleen, lymph nodes, and intestinal epithelium.

Original languageEnglish (US)
Pages (from-to)997-1008
Number of pages12
JournalCell
Volume85
Issue number7
DOIs
StatePublished - Jun 28 1996
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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