Differential requirements for α4 integrins during fetal and adult hematopoiesis

Alicia G. Arroyo, Joy T. Yang, Helen Rayburn, Richard O. Hynes

Research output: Contribution to journalArticlepeer-review


Mice chimeric for the expression of α4 integrins were used to dissect the roles of these receptors in development and traffic of lymphoid and myeloid cells. During fetal life, T cell development is α4 independent, but after birth further production of T cells becomes α4 dependent. Precursors for both T and B cells require α4 integrins for normal development within the bone marrow. In contrast, monocytes and natural killer cells can develop normally without α4 integrins. Thus, there are lymphocyte-specific, developmentally regulated requirements for α4 integrins in hematopoiesis in the bone marrow. We also show that α4 integrins are essential for T cell homing to Peyer's patches, but not to other secondary lymphoid organs, including spleen, lymph nodes, and intestinal epithelium.

Original languageEnglish (US)
Pages (from-to)997-1008
Number of pages12
Issue number7
StatePublished - Jun 28 1996
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology


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