Differential radioprotection of euoxic and hypoxic mouse mammary tumors by a thiophosphate compound

J. F. Utley; T. L. Phillips; L. J. Kane; M. D. Wharam; W. M. Wara

doi:10.1148/110.1.213

Differential radioprotection of euoxic and hypoxic mouse mammary tumors by a thiophosphate compound

J. F. Utley, T. L. Phillips, L. J. Kane, M. D. Wharam, W. M. Wara

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

The radioprotective drug S 2 (3 aminopropylamino)ethyl phosphorothioate (WR2721) was evaluated in the EMT 6 mouse mammary tumor. Under euoxic conditions (DMF approximately 2), the drug protected the oxygenated portion of the tumor but not chronically hypoxic cells. Acutely hypoxic cells were protected to a slight degree. Since WR2721 has been shown to protect normal tissues with a DMF of 2-3, it is likely that decreased protection of anoxic tumor cells will be clinically useful.

Original language	English (US)
Pages (from-to)	213-216
Number of pages	4
Journal	Unknown Journal
Volume	110
Issue number	1
DOIs	https://doi.org/10.1148/110.1.213
State	Published - 1974
Externally published	Yes

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1148/110.1.213

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author = "Utley, {J. F.} and Phillips, {T. L.} and Kane, {L. J.} and Wharam, {M. D.} and Wara, {W. M.}",

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AU - Kane, L. J.

AU - Wharam, M. D.

AU - Wara, W. M.

PY - 1974

Y1 - 1974

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AB - The radioprotective drug S 2 (3 aminopropylamino)ethyl phosphorothioate (WR2721) was evaluated in the EMT 6 mouse mammary tumor. Under euoxic conditions (DMF approximately 2), the drug protected the oxygenated portion of the tumor but not chronically hypoxic cells. Acutely hypoxic cells were protected to a slight degree. Since WR2721 has been shown to protect normal tissues with a DMF of 2-3, it is likely that decreased protection of anoxic tumor cells will be clinically useful.

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Differential radioprotection of euoxic and hypoxic mouse mammary tumors by a thiophosphate compound

Abstract

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