Differential radioprotection of euoxic and hypoxic mouse mammary tumors by a thiophosphate compound

J. F. Utley, T. L. Phillips, L. J. Kane, M. D. Wharam, W. M. Wara

Research output: Contribution to journalArticlepeer-review

Abstract

The radioprotective drug S 2 (3 aminopropylamino)ethyl phosphorothioate (WR2721) was evaluated in the EMT 6 mouse mammary tumor. Under euoxic conditions (DMF approximately 2), the drug protected the oxygenated portion of the tumor but not chronically hypoxic cells. Acutely hypoxic cells were protected to a slight degree. Since WR2721 has been shown to protect normal tissues with a DMF of 2-3, it is likely that decreased protection of anoxic tumor cells will be clinically useful.

Original languageEnglish (US)
Pages (from-to)213-216
Number of pages4
JournalUnknown Journal
Volume110
Issue number1
DOIs
StatePublished - Jan 1 1974

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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