Differential patterns of cognitive impairment in patients with aqueductal stenosis and normal pressure hydrocephalus

A. Donnet, A. Schmitt, H. Dufour, R. Giorgi, F. Grisoli, A. Cohen, Phlippe Decq

Research output: Contribution to journalArticlepeer-review

Abstract

Methods. We report a preoperative neuropsychological evaluation for ten adult patients with aqueductal stenosis, and compare the results of this group with a normal pressure hydrocephalus group. Findings. For executive functions, aqueductal stenosis patients failed on isolated tests and results were heterogeneous; the normal pressure hydrocephalus group was more impaired, except for tasks which required memory processing. Memory deficits in aqueductal stenosis group are qualitatively dissimilar and more homogeneous and severe, despite the younger age, than in the normal pressure hydrocephalus group. Interpretation. These findings indicate that neuropsychological deficits of patients with aqueductal stenosis are linked with fornix damage and frontal dysfunction. In the normal pressure hydrocephalus group, deficits could be linked with a prefrontal lobe disconnection.

Original languageEnglish (US)
Pages (from-to)1301-1308
Number of pages8
JournalActa Neurochirurgica
Volume146
Issue number12
DOIs
StatePublished - Dec 1 2004
Externally publishedYes

Keywords

  • Aqueductal stenosis
  • Memory
  • Normal pressure hydrocephalus

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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