TY - JOUR
T1 - Differential ovarian and adrenal vein catheterization
AU - Wentz, Anne Colston
AU - White, Robert I.
AU - Migeon, Claude J.
AU - Hsu, Tah Hsiung
AU - Barnes, H. Verdain
AU - Jones, Georgeanna Seegar
N1 - Funding Information:
Supported in part by United States Pub& Health Service Training Grant 5-TO 1 HL 05970-03 from the National Heart-Lung Institute (R. I. W.); Research Grant AM 00180-25, Research Career Award 5-iY06-AM 21855-I 0, and the Hospital for Consumptives of Maryland (Eudowood), Baltimore (C. J. M.); and United States Public Health Service Clinical Research Centers Grant RR-35.
PY - 1976/8/1
Y1 - 1976/8/1
N2 - Twenty-two hirsute women underwent percutaneous adrenal and ovarian vein catheterization to differentiate and localize excessive hormonal output. All studies were done under fluoroscopic control; catheter placement was verified by venography, and blood samples were withdrawn for hormonal analysis. The right ovarian vein was successfully sampled in 42 per cent of attempts; the left ovarian vein, in 75 per cent; the right adrenal vein, in 56 per cent; and the left adrenal vein, in 100 per cent. Bilateral catheterization did not prove clinically useful. First, anatomic variations in venous size and drainage made catheterization and bilateral sampling difficult. Second, adrenal secretion is both episodic and parallel, necessitating both simultaneous catheterization and serial sampling for adequate diagnosis. The stress of the procedure may provoke increased adrenal output. Third, since ovarian secretion is not parallel, and since increased hormone output has been documented in that ovary containing developing follicles or a corpus luteum, distinguishing ovarian dysfunction proved difficult. Finally, for a time-consuming procedure, patient discomfort cannot be disregarded. This technique has not proved to be a reliable means of determining the site of androgen hypersecretion and thus cannot be recommended in the routine evaluation of female hirsutism.
AB - Twenty-two hirsute women underwent percutaneous adrenal and ovarian vein catheterization to differentiate and localize excessive hormonal output. All studies were done under fluoroscopic control; catheter placement was verified by venography, and blood samples were withdrawn for hormonal analysis. The right ovarian vein was successfully sampled in 42 per cent of attempts; the left ovarian vein, in 75 per cent; the right adrenal vein, in 56 per cent; and the left adrenal vein, in 100 per cent. Bilateral catheterization did not prove clinically useful. First, anatomic variations in venous size and drainage made catheterization and bilateral sampling difficult. Second, adrenal secretion is both episodic and parallel, necessitating both simultaneous catheterization and serial sampling for adequate diagnosis. The stress of the procedure may provoke increased adrenal output. Third, since ovarian secretion is not parallel, and since increased hormone output has been documented in that ovary containing developing follicles or a corpus luteum, distinguishing ovarian dysfunction proved difficult. Finally, for a time-consuming procedure, patient discomfort cannot be disregarded. This technique has not proved to be a reliable means of determining the site of androgen hypersecretion and thus cannot be recommended in the routine evaluation of female hirsutism.
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U2 - 10.1016/0002-9378(76)90504-4
DO - 10.1016/0002-9378(76)90504-4
M3 - Article
C2 - 941940
AN - SCOPUS:0017175508
SN - 0002-9378
VL - 125
SP - 1000
EP - 1007
JO - American journal of obstetrics and gynecology
JF - American journal of obstetrics and gynecology
IS - 7
ER -