Differential neuronal susceptibility and apoptosis in congenital Zika virus infection

Cheng Ying Ho, Heather M. Ames, Ashley Tipton, Gilbert Vezina, Judy S. Liu, Joseph Scafidi, Masaaki Torii, Fausto J. Rodriguez, Adre du Plessis, Roberta L. DeBiasi

Research output: Contribution to journalArticle

Abstract

To characterize the mechanism of Zika virus (ZIKV)-associated microcephaly, we performed immunolabeling on brain tissue from a 20-week fetus with intrauterine ZIKV infection. Although ZIKV demonstrated a wide range of neuronal and non-neuronal tropism, the infection rate was highest in intermediate progenitor cells and immature neurons. Apoptosis was observed in both infected and uninfected bystander cortical neurons, suggesting a role for paracrine factors in induction of neuronal apoptosis. Our results highlight differential neuronal susceptibility and neuronal apoptosis as potential mechanisms in the development of ZIKV-associated microcephaly, and may provide insights into the design and best timing of future therapy. Ann Neurol 2017;82:121–127.

Original languageEnglish (US)
Pages (from-to)121-127
Number of pages7
JournalAnnals of neurology
Volume82
Issue number1
DOIs
StatePublished - Jul 2017

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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  • Cite this

    Ho, C. Y., Ames, H. M., Tipton, A., Vezina, G., Liu, J. S., Scafidi, J., Torii, M., Rodriguez, F. J., du Plessis, A., & DeBiasi, R. L. (2017). Differential neuronal susceptibility and apoptosis in congenital Zika virus infection. Annals of neurology, 82(1), 121-127. https://doi.org/10.1002/ana.24968