Differentielt neurontab i hippocampus hos normalt aldrende og hos patienter med Alzheimers sygdom.

Translated title of the contribution: Differential neuronal loss in the hippocampus in normal aging and in patients with Alzheimer disease

M. J. West, P. D. Coleman, D. G. Flood, J. C. Troncoso

Research output: Contribution to journalArticle

Abstract

The causal relationship between the neurodegenerative changes that accompany normal ageing and those that characterize Alzheimer's disease is unclear. The high incidence of Alzheimer's disease associated with old age and the presence of its neuropathological signs in non-demented older individuals suggest that these two phenomena involve the same neurodegenerative processes and mechanisms and that Alzheimer's disease is an extension of normal ageing. On the other hand, the identification of environmental and genetic risk factors associated with Alzheimer's disease suggests the involvement of a specific disease process that is not related to normal ageing. The resolution of this fundamental issue is of importance in the design of investigative and therapeutic strategies. In this report, we describe differences in the regional patterns of neuronal loss, in the hippocampal region of the brains of Alzheimer's patients and normal ageing subjects, that indicate that Alzheimer's disease is not the manifestation of accelerated ageing, but the expression of a distinct pathological process.

Translated title of the contributionDifferential neuronal loss in the hippocampus in normal aging and in patients with Alzheimer disease
Original languageDanish
Pages (from-to)3190-3193
Number of pages4
JournalUgeskrift for laeger
Volume157
Issue number22
StatePublished - May 29 1995
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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