Differentielt neurontab i hippocampus hos normalt aldrende og hos patienter med Alzheimers sygdom.

Translated title of the contribution: Differential neuronal loss in the hippocampus in normal aging and in patients with Alzheimer disease

M. J. West, P. D. Coleman, D. G. Flood, Juan C Troncoso

Research output: Contribution to journalArticle

Abstract

The causal relationship between the neurodegenerative changes that accompany normal ageing and those that characterize Alzheimer's disease is unclear. The high incidence of Alzheimer's disease associated with old age and the presence of its neuropathological signs in non-demented older individuals suggest that these two phenomena involve the same neurodegenerative processes and mechanisms and that Alzheimer's disease is an extension of normal ageing. On the other hand, the identification of environmental and genetic risk factors associated with Alzheimer's disease suggests the involvement of a specific disease process that is not related to normal ageing. The resolution of this fundamental issue is of importance in the design of investigative and therapeutic strategies. In this report, we describe differences in the regional patterns of neuronal loss, in the hippocampal region of the brains of Alzheimer's patients and normal ageing subjects, that indicate that Alzheimer's disease is not the manifestation of accelerated ageing, but the expression of a distinct pathological process.

Original languageDanish
Pages (from-to)3190-3193
Number of pages4
JournalUgeskrift for Laeger
Volume157
Issue number22
StatePublished - May 29 1995
Externally publishedYes

Fingerprint

Hippocampus
Alzheimer Disease
Pathologic Processes
Incidence
Brain
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Differentielt neurontab i hippocampus hos normalt aldrende og hos patienter med Alzheimers sygdom. / West, M. J.; Coleman, P. D.; Flood, D. G.; Troncoso, Juan C.

In: Ugeskrift for Laeger, Vol. 157, No. 22, 29.05.1995, p. 3190-3193.

Research output: Contribution to journalArticle

West, M. J. ; Coleman, P. D. ; Flood, D. G. ; Troncoso, Juan C. / Differentielt neurontab i hippocampus hos normalt aldrende og hos patienter med Alzheimers sygdom. In: Ugeskrift for Laeger. 1995 ; Vol. 157, No. 22. pp. 3190-3193.
@article{2542d4786d414c679d9f1b47cec1b98c,
title = "Differentielt neurontab i hippocampus hos normalt aldrende og hos patienter med Alzheimers sygdom.",
abstract = "The causal relationship between the neurodegenerative changes that accompany normal ageing and those that characterize Alzheimer's disease is unclear. The high incidence of Alzheimer's disease associated with old age and the presence of its neuropathological signs in non-demented older individuals suggest that these two phenomena involve the same neurodegenerative processes and mechanisms and that Alzheimer's disease is an extension of normal ageing. On the other hand, the identification of environmental and genetic risk factors associated with Alzheimer's disease suggests the involvement of a specific disease process that is not related to normal ageing. The resolution of this fundamental issue is of importance in the design of investigative and therapeutic strategies. In this report, we describe differences in the regional patterns of neuronal loss, in the hippocampal region of the brains of Alzheimer's patients and normal ageing subjects, that indicate that Alzheimer's disease is not the manifestation of accelerated ageing, but the expression of a distinct pathological process.",
author = "West, {M. J.} and Coleman, {P. D.} and Flood, {D. G.} and Troncoso, {Juan C}",
year = "1995",
month = "5",
day = "29",
language = "Danish",
volume = "157",
pages = "3190--3193",
journal = "Ugeskrift for Laeger",
issn = "0041-5782",
publisher = "Almindelige Danske Laegeforening",
number = "22",

}

TY - JOUR

T1 - Differentielt neurontab i hippocampus hos normalt aldrende og hos patienter med Alzheimers sygdom.

AU - West, M. J.

AU - Coleman, P. D.

AU - Flood, D. G.

AU - Troncoso, Juan C

PY - 1995/5/29

Y1 - 1995/5/29

N2 - The causal relationship between the neurodegenerative changes that accompany normal ageing and those that characterize Alzheimer's disease is unclear. The high incidence of Alzheimer's disease associated with old age and the presence of its neuropathological signs in non-demented older individuals suggest that these two phenomena involve the same neurodegenerative processes and mechanisms and that Alzheimer's disease is an extension of normal ageing. On the other hand, the identification of environmental and genetic risk factors associated with Alzheimer's disease suggests the involvement of a specific disease process that is not related to normal ageing. The resolution of this fundamental issue is of importance in the design of investigative and therapeutic strategies. In this report, we describe differences in the regional patterns of neuronal loss, in the hippocampal region of the brains of Alzheimer's patients and normal ageing subjects, that indicate that Alzheimer's disease is not the manifestation of accelerated ageing, but the expression of a distinct pathological process.

AB - The causal relationship between the neurodegenerative changes that accompany normal ageing and those that characterize Alzheimer's disease is unclear. The high incidence of Alzheimer's disease associated with old age and the presence of its neuropathological signs in non-demented older individuals suggest that these two phenomena involve the same neurodegenerative processes and mechanisms and that Alzheimer's disease is an extension of normal ageing. On the other hand, the identification of environmental and genetic risk factors associated with Alzheimer's disease suggests the involvement of a specific disease process that is not related to normal ageing. The resolution of this fundamental issue is of importance in the design of investigative and therapeutic strategies. In this report, we describe differences in the regional patterns of neuronal loss, in the hippocampal region of the brains of Alzheimer's patients and normal ageing subjects, that indicate that Alzheimer's disease is not the manifestation of accelerated ageing, but the expression of a distinct pathological process.

UR - http://www.scopus.com/inward/record.url?scp=0029653937&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029653937&partnerID=8YFLogxK

M3 - Article

C2 - 7770982

AN - SCOPUS:0029653937

VL - 157

SP - 3190

EP - 3193

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

SN - 0041-5782

IS - 22

ER -