Differential loss of invariant natural killer T cells and FoxP3+ regulatory T cells in HIV-1 subtype A and subtype D infections

Britta Flach, Prossy Naluyima, Kim Blom, Veronica D. Gonzalez, Leigh Anne Eller, Oliver Laeyendecker, Thomas C. Quinn, David Serwadda, Nelson K. Sewankambo, Maria J. Wawer, Ronald H. Gray, Nelson L. Michael, Fred Wabwire-Mangen, Merlin L. Robb, Michael A. Eller, Johan K. Sandberg

Research output: Contribution to journalArticle

Abstract

HIV-1 subtype D is associated with faster disease progression compared with subtype A. Immunological correlates of this difference remain undefined. We investigated invariant natural killer T (iNKT) cells and FoxP3+ regulatory T cells (Tregs) in Ugandans infected with either subtype. Loss of iNKT cells was pronounced in subtype D, whereas Tregs displayed more profound loss in subtype A infection. The iNKT cell levels were associated with CD4 T-cell interleukin-2 production in subtype A, but not in D, infection. Thus, these viral subtypes are associated with differential loss of iNKT cells and Tregs that may influence the quality of the adaptive immune response.

Original languageEnglish (US)
Pages (from-to)289-293
Number of pages5
JournalJournal of acquired immune deficiency syndromes
Volume63
Issue number3
DOIs
StatePublished - Jul 1 2013

Keywords

  • AIDS
  • CD1d
  • HIV-1
  • INKT cell
  • T regulatory cell
  • Viral subtype

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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    Flach, B., Naluyima, P., Blom, K., Gonzalez, V. D., Eller, L. A., Laeyendecker, O., Quinn, T. C., Serwadda, D., Sewankambo, N. K., Wawer, M. J., Gray, R. H., Michael, N. L., Wabwire-Mangen, F., Robb, M. L., Eller, M. A., & Sandberg, J. K. (2013). Differential loss of invariant natural killer T cells and FoxP3+ regulatory T cells in HIV-1 subtype A and subtype D infections. Journal of acquired immune deficiency syndromes, 63(3), 289-293. https://doi.org/10.1097/QAI.0b013e31828b2073