Differential inspiratory timing is genetically linked to mouse chromosome 3

C. G. Tankersley, D. A. DiSilvestre, A. E. Jedlicka, H. M. Wilkins, L. Zhang

Research output: Contribution to journalArticlepeer-review


Genetic control of differential inspiratory timing (TI) at baseline has been previously demonstrated among inbred mouse strains. The inheritance pattern for TI between C3H/HeJ (C3; 188 ± 3 ms) and C57BL/6J (B6; 111 ± 2 ms) progenitors was consistent with a two-gene model. By using the strain distribution pattern for recombinant inbred strains derived from C3 and B6 progenitors, 100% concordance was established between TI phenotypes and DNA markers on mouse chromosome 3. This genotype-phenotype hypothesis was tested by typing 52 B6C3F2 (F2) progeny by using simple sequence repeat DNA markers (n = 21) polymorphic between C3 and B6 strains on mouse chromosome 3. Linkage analysis compared marker genotypes to baseline ventilatory phenotypes by computing log-likelihood values. A putative quantitative trait locus located in proximity to D3Mit119 was significantly associated with baseline TI phenotypes. At the peak (log-likelihood = 3.3), the putative quantitative trait locus determined 25% of the phenotypic variance in TI among F2 progeny. In conclusion, this genetic model of ventilatory characteristics demonstrated an important linkage between differential baseline TI and a candidate genomic region on mouse chromosome 3.

Original languageEnglish (US)
Pages (from-to)360-365
Number of pages6
JournalJournal of applied physiology
Issue number1
StatePublished - Jul 1998


  • BXH recombinant inbred strains
  • C3H/HeJ
  • C57BL/6J
  • Control of breathing
  • Linkage analysis

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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