Differential induction of the androgen receptor transcriptional activity by selective androgen receptor coactivators

Shuyuan Yeh, Hong Chiang Chang, Hiroshi Miyamoto, Hiroshi Takatera, Mujib Rahman, Hong Yo Kang, Tin Htwe Thin, Hui Kuan Lin, Chawnshang Chang

Research output: Contribution to journalReview article

Abstract

Several new androgen receptor (AR) cofactors, associated to the ligand binding domain of AR, have been identified by our group and named AR associated protein (ARA)70, ARA55, and ARA54. Our previous reports have suggested that the cofactor ARA70 can confer the androgenic effect from 17 β-estradiol (E2) and antiandrogen to AR. It is of interest for us to compare and determine if the specificity of sex hormones and antiandrogens could be modulated by different coactivators. Our results indicate that ARA70 is the best coactivator to confer the androgenic activity on E2. Only ARA70 and ARA55 could increase significantly the androgenic activity of hydroxyflutamide, a widely used antiandrogen for the treatment of prostate cancer. Furthermore, as compared to the relative specificity of these coactivators to AR in the prostate cancer DU145 cells, our results suggest that ARA70 has a relatively higher specificity. Together, our data suggest that the specificity of sex hormones and antiandrogens can be modulated by some selective AR coactivators. These findings may not only help us to better understand the specificity of the sex hormones and antiandrogens, but also to facilitate the development of better antiandrogens or androgens to fight the androgen-related diseases, such as prostate cancer.

Original languageEnglish (US)
Pages (from-to)87-92
Number of pages6
JournalKeio Journal of Medicine
Volume48
Issue number2
DOIs
StatePublished - Jun 1999

Keywords

  • ARA54
  • ARA55
  • ARA70
  • Rb
  • SRC-1

ASJC Scopus subject areas

  • Medicine(all)

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    Yeh, S., Chang, H. C., Miyamoto, H., Takatera, H., Rahman, M., Kang, H. Y., Thin, T. H., Lin, H. K., & Chang, C. (1999). Differential induction of the androgen receptor transcriptional activity by selective androgen receptor coactivators. Keio Journal of Medicine, 48(2), 87-92. https://doi.org/10.2302/kjm.48.87