Differential expression of voltage-gated sodium channels in afferent neurons renders selective neural block by ionic direct current

Fei Yang, Michael Anderson, Shao-Qiu He, Kimberly Stephens, Yu Zheng, Zhiyong Chen, Srinivasa Naga Raja, Felix Aplin, Yun Guan, Gene Y Fridman

Research output: Contribution to journalArticle

Abstract

The assertion that large-diameter nerve fibers have low thresholds and small-diameter fibers have high thresholds in response to electrical stimulation has been held in a nearly axiomatic regard in the field of neuromodulation and neuroprosthetics. In contrast to the short pulses used to evoke action potentials, long-duration ionic direct current has been shown to block neural activity. We propose that the main determinant of the neural sensitivity to direct current block is not the size of the axon but the types of voltage-gated sodium channels prevalent in its neural membrane. On the basis of the variants of voltage-gated sodium channels expressed in different types of neurons in the peripheral nerves, we hypothesized that the small-diameter nociceptive fibers could be preferentially blocked. We show the results of a computational model and in vivo neurophysiology experiments that offer experimental validation of this novel phenomenon.

Original languageEnglish (US)
Article numbereaaq1438
JournalScience advances
Volume4
Issue number4
DOIs
StatePublished - Apr 11 2018

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Voltage-Gated Sodium Channels
Afferent Neurons
Neurophysiology
Peripheral Nerves
Nerve Fibers
Electric Stimulation
Action Potentials
Axons
Neurons
Membranes

ASJC Scopus subject areas

  • General

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Differential expression of voltage-gated sodium channels in afferent neurons renders selective neural block by ionic direct current. / Yang, Fei; Anderson, Michael; He, Shao-Qiu; Stephens, Kimberly; Zheng, Yu; Chen, Zhiyong; Raja, Srinivasa Naga; Aplin, Felix; Guan, Yun; Fridman, Gene Y.

In: Science advances, Vol. 4, No. 4, eaaq1438, 11.04.2018.

Research output: Contribution to journalArticle

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AU - Anderson, Michael

AU - He, Shao-Qiu

AU - Stephens, Kimberly

AU - Zheng, Yu

AU - Chen, Zhiyong

AU - Raja, Srinivasa Naga

AU - Aplin, Felix

AU - Guan, Yun

AU - Fridman, Gene Y

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