Differential expression of voltage-gated sodium channels in afferent neurons renders selective neural block by ionic direct current

Fei Yang, Michael Anderson, Shaoqiu He, Kimberly Stephens, Yu Zheng, Zhiyong Chen, Srinivasa N. Raja, Felix Aplin, Yun Guan, Gene Fridman

Research output: Contribution to journalArticlepeer-review

Abstract

The assertion that large-diameter nerve fibers have low thresholds and small-diameter fibers have high thresholds in response to electrical stimulation has been held in a nearly axiomatic regard in the field of neuromodulation and neuroprosthetics. In contrast to the short pulses used to evoke action potentials, long-duration ionic direct current has been shown to block neural activity. We propose that the main determinant of the neural sensitivity to direct current block is not the size of the axon but the types of voltage-gated sodium channels prevalent in its neural membrane. On the basis of the variants of voltage-gated sodium channels expressed in different types of neurons in the peripheral nerves, we hypothesized that the small-diameter nociceptive fibers could be preferentially blocked. We show the results of a computational model and in vivo neurophysiology experiments that offer experimental validation of this novel phenomenon.

Original languageEnglish (US)
Article numbereaaq1438
JournalScience Advances
Volume4
Issue number4
DOIs
StatePublished - Apr 11 2018

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Differential expression of voltage-gated sodium channels in afferent neurons renders selective neural block by ionic direct current'. Together they form a unique fingerprint.

Cite this