Differential expression of aquaporin-4 isoforms localizes with neuromyelitis optica disease activity

Harleen Saini, Gregory Fernandez, Douglas Kerr, Michael Levy

Research output: Contribution to journalArticle

Abstract

Neuromyelitis optica (NMO) is a devastating neuroinflammatory disorder that specifically targets the spinal cord and optic nerves. Aquaporin-4 (AQP4) is the target of the NMO-IgG biomarker. AQP4 is expressed as two isoforms: M1 and M23, which have different functions in the central nervous system (CNS). We characterized the expression pattern of these AQP4 isoform mRNAs in humans and found a pattern of AQP4 expression that correlates with NMO disease localization. The ratio of M1:M23 mRNA is highest in the optic nerve and spinal cord, followed by brainstem, then the cerebral and cerebellar cortices.

Original languageEnglish (US)
Pages (from-to)68-72
Number of pages5
JournalJournal of Neuroimmunology
Volume221
Issue number1-2
DOIs
StatePublished - Apr 1 2010

Keywords

  • Aquaporin-4
  • Aquaporin-4 isoforms M1 and M23
  • Astrocytes
  • Neuromyelitis optica
  • Rapid amplification of DNA ends (RACE)

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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