Differential expression of amyloid precursor protein mRNAs in cases of Alzheimer's disease and in aged nonhuman primates

Edward H. Koo, Sangram S. Sisodia, Linda C. Cork, Axel Unterbeck, Richard M. Bayney, Donald L. Price

Research output: Contribution to journalArticle

Abstract

Senile plaques are a characteristic feature in brains of individuals with Alzheimer's disease (AD) and aged monkeys. The principal component of amyloid in senile plaques is β/A4, a peptide derived from a larger amyloid precursor protein (APP). To date, several alternatively spliced APP transcripts have been described. The relationship between levels of these APP mRNAs and amyloid deposition is unclear. In this study, we directly measured the relative levels of APP transcripts that lack the protease inhibitor domain (APP-695) and transcripts that encode the inhibitor sequences (APP-751/770). Our results indicate that the expression of APP mRNAs is not selectively altered in AD cortex. Moreover, the differential expression of APP transcripts is not correlated with the deposition of amyloid in cases of AD and aged monkeys. These findings suggest that other factors, not directly related to the relative expression of APP mRNAs, may contribute to amyloidogenesis in the brain.

Original languageEnglish (US)
Pages (from-to)97-104
Number of pages8
JournalNeuron
Volume4
Issue number1
DOIs
StatePublished - Jan 1990

ASJC Scopus subject areas

  • Neuroscience(all)

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