Differential effects of stress and African ancestry on preterm birth and related traits among US born and immigrant Black mothers

Hui Ju Tsai, Pamela Surkan, Stella M. Yu, Deanna Caruso, Xiumei Hong, Tami R. Bartell, Anastacia D. Wahl, Claire Sampankanpanich, Anne Reily, Barry S. Zuckerman, Xiaobin Wang

Research output: Contribution to journalArticle

Abstract

Preterm birth (PTB, <37 weeks of gestation) is influenced by a wide range of environmental, genetic and psychosocial factors, and their interactions. However, the individual and joint effects of genetic factors and psychosocial stress on PTB have remained largely unexplored among U.S. born versus immigrant mothers. We studied 1121 African American women from the Boston Birth Cohort enrolled from 1998 to 2008. Regression-based analyses were performed to examine the individual and joint effects of genetic ancestry and stress (including lifetime stress [LS] and stress during pregnancy [PS]) on PTB and related traits among U.S. born and immigrant mothers. Significant associations between LS and PTB and related traits were found in the total study population and in immigrant mothers, including gestational age, birthweight, PTB, and spontaneous PTB; but no association was found in U.S. born mothers. Furthermore, significant joint associations of LS (or PS) and African ancestral proportion (AAP) on PTB were found in immigrant mothers, but not in U.S. born mothers. Although, overall, immigrant women had lower rates of PTB compared to U.S. born women, our study is one of the first to identify a subset of immigrant women could be at significantly increased risk of PTB and related outcomes if they have high AAP and are under high LS or PS. In light of the growing number of immigrant mothers in the U.S., our findings may have important clinical and public health implications.

Original languageEnglish (US)
Article number00046
JournalMedicine (United States)
Volume96
Issue number5
DOIs
StatePublished - Feb 1 2017

Fingerprint

Premature Birth
Mothers
Psychology
Pregnancy
African Americans
Gestational Age
Public Health
Regression Analysis
Parturition
Population

Keywords

  • genetic ancestry
  • preterm birth
  • stress

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Differential effects of stress and African ancestry on preterm birth and related traits among US born and immigrant Black mothers. / Tsai, Hui Ju; Surkan, Pamela; Yu, Stella M.; Caruso, Deanna; Hong, Xiumei; Bartell, Tami R.; Wahl, Anastacia D.; Sampankanpanich, Claire; Reily, Anne; Zuckerman, Barry S.; Wang, Xiaobin.

In: Medicine (United States), Vol. 96, No. 5, 00046, 01.02.2017.

Research output: Contribution to journalArticle

Tsai, Hui Ju ; Surkan, Pamela ; Yu, Stella M. ; Caruso, Deanna ; Hong, Xiumei ; Bartell, Tami R. ; Wahl, Anastacia D. ; Sampankanpanich, Claire ; Reily, Anne ; Zuckerman, Barry S. ; Wang, Xiaobin. / Differential effects of stress and African ancestry on preterm birth and related traits among US born and immigrant Black mothers. In: Medicine (United States). 2017 ; Vol. 96, No. 5.
@article{50fe4298f1db4eb898e143ee4f5f0b1b,
title = "Differential effects of stress and African ancestry on preterm birth and related traits among US born and immigrant Black mothers",
abstract = "Preterm birth (PTB, <37 weeks of gestation) is influenced by a wide range of environmental, genetic and psychosocial factors, and their interactions. However, the individual and joint effects of genetic factors and psychosocial stress on PTB have remained largely unexplored among U.S. born versus immigrant mothers. We studied 1121 African American women from the Boston Birth Cohort enrolled from 1998 to 2008. Regression-based analyses were performed to examine the individual and joint effects of genetic ancestry and stress (including lifetime stress [LS] and stress during pregnancy [PS]) on PTB and related traits among U.S. born and immigrant mothers. Significant associations between LS and PTB and related traits were found in the total study population and in immigrant mothers, including gestational age, birthweight, PTB, and spontaneous PTB; but no association was found in U.S. born mothers. Furthermore, significant joint associations of LS (or PS) and African ancestral proportion (AAP) on PTB were found in immigrant mothers, but not in U.S. born mothers. Although, overall, immigrant women had lower rates of PTB compared to U.S. born women, our study is one of the first to identify a subset of immigrant women could be at significantly increased risk of PTB and related outcomes if they have high AAP and are under high LS or PS. In light of the growing number of immigrant mothers in the U.S., our findings may have important clinical and public health implications.",
keywords = "genetic ancestry, preterm birth, stress",
author = "Tsai, {Hui Ju} and Pamela Surkan and Yu, {Stella M.} and Deanna Caruso and Xiumei Hong and Bartell, {Tami R.} and Wahl, {Anastacia D.} and Claire Sampankanpanich and Anne Reily and Zuckerman, {Barry S.} and Xiaobin Wang",
year = "2017",
month = "2",
day = "1",
doi = "10.1097/MD.0000000000005899",
language = "English (US)",
volume = "96",
journal = "Medicine (United States)",
issn = "0025-7974",
publisher = "Lippincott Williams and Wilkins Ltd.",
number = "5",

}

TY - JOUR

T1 - Differential effects of stress and African ancestry on preterm birth and related traits among US born and immigrant Black mothers

AU - Tsai, Hui Ju

AU - Surkan, Pamela

AU - Yu, Stella M.

AU - Caruso, Deanna

AU - Hong, Xiumei

AU - Bartell, Tami R.

AU - Wahl, Anastacia D.

AU - Sampankanpanich, Claire

AU - Reily, Anne

AU - Zuckerman, Barry S.

AU - Wang, Xiaobin

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Preterm birth (PTB, <37 weeks of gestation) is influenced by a wide range of environmental, genetic and psychosocial factors, and their interactions. However, the individual and joint effects of genetic factors and psychosocial stress on PTB have remained largely unexplored among U.S. born versus immigrant mothers. We studied 1121 African American women from the Boston Birth Cohort enrolled from 1998 to 2008. Regression-based analyses were performed to examine the individual and joint effects of genetic ancestry and stress (including lifetime stress [LS] and stress during pregnancy [PS]) on PTB and related traits among U.S. born and immigrant mothers. Significant associations between LS and PTB and related traits were found in the total study population and in immigrant mothers, including gestational age, birthweight, PTB, and spontaneous PTB; but no association was found in U.S. born mothers. Furthermore, significant joint associations of LS (or PS) and African ancestral proportion (AAP) on PTB were found in immigrant mothers, but not in U.S. born mothers. Although, overall, immigrant women had lower rates of PTB compared to U.S. born women, our study is one of the first to identify a subset of immigrant women could be at significantly increased risk of PTB and related outcomes if they have high AAP and are under high LS or PS. In light of the growing number of immigrant mothers in the U.S., our findings may have important clinical and public health implications.

AB - Preterm birth (PTB, <37 weeks of gestation) is influenced by a wide range of environmental, genetic and psychosocial factors, and their interactions. However, the individual and joint effects of genetic factors and psychosocial stress on PTB have remained largely unexplored among U.S. born versus immigrant mothers. We studied 1121 African American women from the Boston Birth Cohort enrolled from 1998 to 2008. Regression-based analyses were performed to examine the individual and joint effects of genetic ancestry and stress (including lifetime stress [LS] and stress during pregnancy [PS]) on PTB and related traits among U.S. born and immigrant mothers. Significant associations between LS and PTB and related traits were found in the total study population and in immigrant mothers, including gestational age, birthweight, PTB, and spontaneous PTB; but no association was found in U.S. born mothers. Furthermore, significant joint associations of LS (or PS) and African ancestral proportion (AAP) on PTB were found in immigrant mothers, but not in U.S. born mothers. Although, overall, immigrant women had lower rates of PTB compared to U.S. born women, our study is one of the first to identify a subset of immigrant women could be at significantly increased risk of PTB and related outcomes if they have high AAP and are under high LS or PS. In light of the growing number of immigrant mothers in the U.S., our findings may have important clinical and public health implications.

KW - genetic ancestry

KW - preterm birth

KW - stress

UR - http://www.scopus.com/inward/record.url?scp=85013218780&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85013218780&partnerID=8YFLogxK

U2 - 10.1097/MD.0000000000005899

DO - 10.1097/MD.0000000000005899

M3 - Article

C2 - 28151865

AN - SCOPUS:85013218780

VL - 96

JO - Medicine (United States)

JF - Medicine (United States)

SN - 0025-7974

IS - 5

M1 - 00046

ER -